PMID: 309303Jun 12, 1978Paper

Effects of serotonin neurotoxins on rotational behavior in the rat

Annals of the New York Academy of Sciences
C T GiambalvoN J Uretsky

Abstract

Injections of p-CA or 5,7-DHT into the MRN caused decreases in 5-HT and 5-HIAA levels in the cortex and striatum. They also caused a decrease in 5-HT turnover in the cortex and an increase in striatal DA turnover. The unilaterally injected rats showed contralateral rotation after amphetamine or apomorphine administration. There was a significant correlation among the rate of rotation, the decrease in cortical 5-HT turnover, and the increase in striatal DA turnover. Injection of 5,7-DHT into the SN produced the same biochemical and behavioral changes as did MRN lesions, suggesting that the changes induced by MRN lesions might be due to a direct projection from the raphe to the substantia nigra. Injection of 5,7-DHT into the MFB caused ipsilateral rotation after injection of amphetamine or apomorphine and a decrease in DA turnover in the striatum. There was a significant correlation among the rate of rotation, the decrease in 5-HT turnover in the cortex, and the decrease in striatal DA turnover in the MFB-lesioned rats. These effects might be due to a projection from the DRN to cell bodies in the striatum.

References

Sep 1, 1975·The Journal of Pharmacy and Pharmacology·F JavoyJ Glowinski
Dec 16, 1977·Brain Research·J C JacksonR M Benjamin
May 1, 1976·Life Sciences·S D GlickL N Fleisher
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Jan 1, 1966·Brain Research·W J Nauta, W R Mehler
Jan 1, 1966·Acta Pharmacologica Et Toxicologica·N E AndénK Larsson

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