PMID: 9192540Apr 1, 1997Paper

Effects of serotonin reuptake inhibitors on aggressive behavior in psychiatrically hospitalized adolescents: results of an open trial

Journal of Child and Adolescent Psychopharmacology
J N ConstantinoM Kincaid

Abstract

Low concentrations of the neurotransmitter serotonin and its 5-hydroxyindoleacetic acid metabolite in the central nervous system have been associated with increased aggressive behavior in animals and humans. Controlled clinical trials of serotonin agonists in depressed adults have suggested that aggressive behavior is less likely during treatment with these medications than with placebo, but there have been no previous studies of selective serotonin reuptake inhibitors (SSRIs) and aggression in children. We prospectively followed the course of aggressive behavior in 19 psychiatrically hospitalized adolescents (not selected for aggressiveness) who received open clinical trials of fluoxetine, paroxetine, or sertraline. The patients received standard doses (equivalent to fluoxetine 10-40 mg daily) for a minimum of 5 weeks. The starting dose was 15 +/- 5 mg, and dosages were raised at a mean rate of 5 mg every 4 days up to a mean dose of 25 +/- 10 mg daily. Results from trials of the three SSRIs were clustered because the sample sizes were not sufficient for separate analyses. Overall, there were no statistically meaningful improvements in the level of aggressive behavior, as measured on a modified version of the Overt Aggression S...Continue Reading

References

Jun 1, 1982·The American Journal of Psychiatry·G L BrownF K Goodwin
Feb 1, 1995·Journal of Clinical Psychopharmacology·C SalzmanE Miyawaki
Jun 1, 1996·Archives of General Psychiatry·E F CoccaroJ G Csernansky

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Citations

Jun 8, 1999·Psychiatry Research·R A ClarkeJ N Constantino
Jul 9, 2008·Development and Psychopathology·Stephanie H M van Goozen, Graeme Fairchild
Jan 28, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·J E Lafferty, J N Constantino
Jun 19, 2007·American Journal of Preventive Medicine·Mary Ann LimbosMichele D Kipke
Mar 11, 2006·Child and Adolescent Psychiatric Clinics of North America·Marie V SollerHans Steiner
Aug 3, 2016·Journal of Child and Adolescent Psychopharmacology·Samuel Kim, Khrista Boylan
Aug 5, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Lindley Bassarath
Jun 1, 2021·Child and Adolescent Psychiatric Clinics of North America·Carrie VaudreuilJanet Wozniak

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