Effects of serotonin through serotonin1A and serotonin4 receptors on inhibition in the guinea-pig dentate gyrus in vitro

Neuroscience
M Bijak, U Misgeld

Abstract

The role of serotonin1A and serotonin4 receptors in the modulation of synaptic inhibition in the dentate gyrus of guinea-pig hippocampal slices was studied. The effects of serotonin (5-hydroxytryptamine) on hilar neurons and on inhibitory postsynaptic potentials in granule cells were compared using intracellular recording in the presence of glutamatergic receptor antagonists. On the basis of electrophysiological properties hilar neurons were classified as type I neurons (presumably inhibitory) and type II neurons (presumably excitatory). Serotonin hyperpolarized a proportion of type I hilar neurons (60%) and decreased their input resistance through activation of a K+-conductance. This effect was mediated by serotonin1A receptors since it was mimicked by the selective serotonin1A receptor agonist (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide and blocked by the selective serotonin1A receptor antagonist (+) WAY 100135. In some type I hilar neurons (40%) neither serotonin nor (+/-)-8-hydroxydipropylaminotetralin hydrobromide induced a membrane hyperpolarization. Instead, serotonin induced an excitatory response, depolarizing the cells and blocking the slow afterhyperpolarization. Similar effects were seen in all hilar neurons ...Continue Reading

References

Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T F FreundK Tóth
Jul 17, 1990·European Journal of Pharmacology·Y ChaputR Andrade
Jan 1, 1990·Experimental Brain Research·G Richter-Levin, M Segal
Jan 1, 1990·Neuroscience·S Oleskevich, L Descarries
Dec 1, 1994·Trends in Neurosciences·I ModyI Soltesz
Dec 15, 1994·The Journal of Physiology·P Piguet, M Galvan
Feb 1, 1994·Hippocampus·E Soriano, M Frotscher
Jun 24, 1993·European Journal of Pharmacology·A FletcherY Reilly
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L H TecottD Julius
Jan 1, 1992·The European Journal of Neuroscience·K. HalasyT. F. Freund

❮ Previous
Next ❯

Citations

Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jong-Ju LeeYoung-Wuk Cho
Nov 16, 2013·Experimental Brain Research·Mohammad Hadi GharedaghiReza Rahimian
May 4, 2013·Hippocampus·Aine M DuffyHelen E Scharfman
Dec 18, 2013·The Journal of Pharmacy and Pharmacology·Tyra S C ZetterströmAhmad A Khundakar
Sep 21, 2011·European Journal of Pharmacology·Ahmad A Khundakar, Tyra S C Zetterström
Mar 11, 2016·Journal of Neurophysiology·Kanako NozakiYasuo Furukawa
Apr 4, 2020·Psychological Medicine·Susannah E MurphyCatherine J Harmer
Nov 16, 2018·International Journal of Molecular Sciences·Heike RebholzJulia Castello
Sep 20, 2019·Neural Plasticity·Hannah L BernsteinHelen E Scharfman
Feb 15, 2013·Pharmacological Reports : PR·Krzysztof TokarskiGrzegorz Hess
Dec 4, 2003·Brain Research·Krzysztof TokarskiGrzegorz Hess

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.