Effects of serum testosterone level with buserelin on the activities of drug and testosterone hydroxylase and on the content of a male-specific form of cytochrome P-450 in male rats

Biochemical Pharmacology
H OhiT Kamataki

Abstract

The effects of administration of buserelin, a synthetic agonist of lutenizing hormone-releasing hormone (LH-RH), on the content of P-450-male, a male specific form of cytochrome P-450, and the activities of drug and testosterone hydroxylases were examined in liver microsomes of male rats. Administration of buserelin resulted in a decrease in the serum level of testosterone in a dose-dependent manner. Similar decreases were seen in the activities of aminopyrine N-demethylase, 7-propoxycoumarin O-depropylase and testosterone 2 alpha- and 16 alpha-hydroxylases, but not in the activity of aniline p-hydroxylase. Thus, correlations were observed between the serum level of testosterone and the activities of drug and testosterone hydroxylases except for aniline p-hydroxylase. These results indicate that the drug and testosterone hydroxylases are affected sensitively and sequentially by the changes in the testosterone levels in the body.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Nov 1, 1977·Journal of Biochemistry·Y ImaiT Iyanagi
Apr 1, 1978·Analytical Biochemistry·A Aitio
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
Oct 1, 1970·Steroids·S FuruyamaC A Nugent
Jan 1, 1983·Annual Review of Physiology·J A GustafssonP Skett

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Citations

Jan 1, 1996·Drug and Chemical Toxicology·K V Ramana, K K Kohli
Dec 14, 1999·Alimentary Pharmacology & Therapeutics·M ToniniF Crema
May 7, 1992·Biochimica Et Biophysica Acta·M KomoriT Kamataki

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