Effects of sevelamer hydrochloride on mortality, lipid abnormality and arterial stiffness in hemodialyzed patients: a propensity-matched observational study.

Clinical and Experimental Nephrology
Soichiro IimoriYusuke Tsukamoto

Abstract

Cause-and-effect associations between sevelamer hydrochloride (HCl) and mortality have yet to be clarified. The effects of sevelamer HCl on mortality, lipid abnormality and arterial stiffness were examined in patients with chronic kidney disease stage 5D. The effects of sevelamer HCl were studied by a single-center cohort study that was conducted from January 1, 2005 to December 31, 2008 (n = 483). By the end of the study, 172 patients (Sevelamer group) had succeeded in continuing sevelamer HCl for >6 months (median 37 months), and 300 patients (Control group) had received calcium carbonate (n = 264) or no phosphate binder (n = 36). The mortality and other outcomes were compared between these two groups after matching by a propensity score calculated using age, gender, diabetes prevalence, and dialysis vintage. All-cause [hazard ratio (HR) 0.4, P = 0.02] and cardiovascular (CV)-cause [HR 0.29, P = 0.03] cumulative mortality were significantly lower in the matched Sevelamer group than in the matched Control group. The matched Sevelamer group showed increased high-density lipoprotein cholesterol (P = 0.003) and no change in pulse wave velocity (PWV) and ankle-brachial index (ABI), whereas the matched Control group showed increase...Continue Reading

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Citations

Jul 30, 2014·Néphrologie & thérapeutique·Ziad A Massy, Julien Maizel
Aug 25, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Laura Rodríguez-OsorioEmilio González Parra
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Aug 31, 2017·Clinical Kidney Journal·Claudia YusteManuel Praga
Jun 24, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jin Hee LeeSuk-Kyun Yang

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