PMID: 1211314Oct 1, 1975Paper

Effects of seven anthracycline antibiotics on electrocardiogram and mitochondrial function of rat hearts

Agents and Actions
E BachmannG Zbinden

Abstract

Daunomycin, adriamycin and 5 semisynthetic anthracycline antibiotics inhibited oxygen consumption or ATP production of rat heart mitochondria in vitro. The no-effect levels varied depending on the substrate used and ranged from 1 nmole per mg mitochondrial protein. Mitochondrial functions were also studied in hearts of rats treated with repeated i.p. injections of the 7 antibiotics. Decrease in oxygen consumption without change in ATP production was observed with adriamycin and NSC-149584. Daunomycin, NSC-164011, NSC-143496 NSC-143114 affected primarily ATP production. The most potent compounds were daunomycin and adriamycin which damaged mitochondrial function at cummulative doses of approximately 10 mg/kg. ECGs were monitored in groups of equally treated rats. Cardiotoxicity manifested itself by progressive widening of the QRS complex often followed by the development of a S-wave trough. The most toxic compounds also induced intraventricular block, bradycardia and heart failure. The development of the ECG changes showed a good correlation with the impairment of mitochondrial function.

References

Mar 1, 1977·Agents and Actions·G ZbindenM Pfister
Jun 4, 1974·Biochemical and Biophysical Research Communications·Y IwamotoK Folkers
Mar 1, 1969·Lancet·J S Malpas, R B Scott
Apr 19, 1969·Lancet·G Bonadonna, S Monfardini
Oct 1, 1973·Cancer·L M BujaE S Henderson
Aug 1, 1974·Journal of the National Cancer Institute·C CargillG Zbinden
Oct 1, 1974·Annals of Internal Medicine·J J RinehartS P Balcerzak
Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Sep 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M GosalvezB Chance
Feb 1, 1974·Annals of Internal Medicine·R H Blum, S K Carter
Sep 14, 1972·Biochimica Et Biophysica Acta·F ZuninoA Zaccara
Apr 1, 1973·Pathology·S C ChalcroftP B Herdson
Jul 27, 1968·British Medical Journal·J S Malpas, R B Scott
Aug 30, 1969·British Medical Journal·G BonadonnaF Fossati-Bellani
Feb 15, 1964·Nature·A DIMARCOL VALENTINI
May 11, 1965·Biochimica Et Biophysica Acta·E CALENDIL VALENTINI

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Citations

Sep 30, 2006·Cell Biology and Toxicology·J M Berthiaume, K B Wallace
Jan 1, 1986·Progress in Biophysics and Molecular Biology·H Porumb, I Petrescu
Jan 1, 1987·Pharmacology & Therapeutics·G Powis
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C M Czarnecki
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T KishiK Folkers
Oct 1, 1978·Environmental Health Perspectives·T Balazs, V J Ferrans
Apr 1, 1990·Biophysical Chemistry·E GoormaghtighJ M Ruysschaert
Sep 3, 1984·Biochimica Et Biophysica Acta·E Goormaghtigh, J M Ruysschaert
Jan 1, 1979·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·H Brunner, F Gross
Jun 30, 2011·Expert Opinion on Therapeutic Patents·Anna-Maria Katsori, Dimitra Hadjipavlou-Litina
Jul 18, 1988·FEBS Letters·G V Rumyantseva, L M Weiner
Dec 5, 1984·Biochimica Et Biophysica Acta·K NicolayB De Kruijff
Jan 14, 1983·Biochemical and Biophysical Research Communications·T C NgJ D Glickson
Mar 1, 1977·Pharmacological Research Communications·C Bertazzoli, M Ghione
Nov 1, 1984·Biochemical Pharmacology·P M Sokolove
Nov 1, 1980·Biochemical Pharmacology·E GoormaghtighJ M Ruysschaert
Jan 15, 1982·Biochemical and Biophysical Research Communications·E GoormaghtighJ M Ruysschaert
Mar 1, 1983·Biochemical Pharmacology·E GoormaghtighJ M Ruysschaert
Jun 8, 2017·Genetics and Molecular Biology·Iara Maluf TomazellaJosé Maurício Barbanti Duarte
Dec 21, 2004·Toxicologic Pathology·Luksana ChaiswingTerry D Oberley
Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A M KellerL M Buja
May 24, 2019·Circulation Research·Joshua A CowgillDouglas B Sawyer
Dec 15, 1988·Biochemical Pharmacology·M PraetJ M Ruysschaert
Jun 16, 1986·Biochimica Et Biophysica Acta·K NicolayB de Kruijff
Jan 13, 1983·Biochimica Et Biophysica Acta·H MuhammedC K Kurup
Nov 1, 1984·Cancer Letters·M PraetJ M Ruysschaert

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