Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial

FEMS Immunology and Medical Microbiology
Damien PaineauArthur C Ouwehand

Abstract

This pilot study investigated the immunomodulatory properties of seven probiotic strains. Eighty-three healthy volunteers aged 18-62 years consumed 2 x 10(10) CFU of bacteria or a placebo (maltodextrin) over 3 weeks (D0-D21). Subjects received an oral cholera vaccine at D7 and at D14; blood and saliva samples were collected at D0, D21 and D28. Serum samples were analyzed for specific IgA, IgG and IgM, and saliva samples were analyzed for specific IgA only, by ELISA. Statistical analyses were based on Wilcoxon's signed-rank test (intragroup analyses) and exact median t-test (intergroup analyses). Salivary analysis showed no difference in specific IgA concentrations between groups. Serum analysis indicated an effect of some of the tested strains on specific humoral responses. Between D0 and D21, IgG increased in two probiotic groups, for example, Bifidobacterium lactis Bl-04 and Lactobacillus acidophilus La-14, compared with controls (P=0.01). Trends toward significant changes in immunoglobulin serum concentrations compared with controls (P<0.1) were found for six out of the seven probiotic strains. In conclusion, some strains of probiotics demonstrated a faster immune response measured with serum immunoglobulin indicators, espec...Continue Reading

References

Nov 1, 1994·FEMS Immunology and Medical Microbiology·H Link-AmsterJ M Aeschlimann
Feb 7, 2001·The American Journal of Clinical Nutrition·E IsolauriS Salminen
Apr 3, 2002·Pediatrics·Cornelius W Van NielDimitri A Christakis
Sep 18, 2003·FEMS Immunology and Medical Microbiology·Karen Manon LammersMassimo Campieri
Sep 11, 2004·Journal of Applied Microbiology·C Maldonado Galdeano, G Perdigón
Dec 4, 2004·European Journal of Nutrition·Michael de VreseJürgen Schrezenmeir
Jul 1, 2006·Nutrition Reviews·Sylvia SantosaPeter J H Jones
Aug 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kaarina KukkonenMikael Kuitunen
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jose M Saavedra

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Citations

Nov 8, 2011·The British Journal of Nutrition·Honglin DongParveen Yaqoob
Jun 22, 2010·Applied and Environmental Microbiology·Yong Jun Goh, Todd R Klaenhammer
Jun 22, 2013·Genome Announcements·Buffy Stahl, Rodolphe Barrangou
Apr 21, 2009·Journal of Bacteriology·Rodolphe BarrangouRobert F Roberts
Aug 21, 2010·Canadian Journal of Microbiology·Sophie Coudeyras, Christiane Forestier
Nov 25, 2011·Gastroenterology Research and Practice·J William CritchfieldPaul Ashwood
May 15, 2013·BMC Genomics·Joakim M AndersenTodd R Klaenhammer
Oct 26, 2011·Microbial Cell Factories·Jerry M Wells
Dec 3, 2010·PLoS Pathogens·Rosana B R FerreiraB Brett Finlay
Aug 13, 2014·Trends in Immunology·Yanet ValdezB Brett Finlay
Jul 7, 2011·Nutrition Reviews·Taylor C WallaceMary Ellen Sanders
Nov 29, 2014·Expert Opinion on Biological Therapy·Metehan OzenEner Cagri Dinleyici
Oct 31, 2009·Ageing Research Reviews·Kirsti TiihonenNina Rautonen
Oct 16, 2015·Microbial Ecology in Health and Disease·Sofia D ForsstenArthur C Ouwehand
Jun 29, 2011·FEMS Immunology and Medical Microbiology·Monika GadSimon S Jensen
May 13, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ira PraharajGagandeep Kang
Nov 26, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicholas P WestAllan W Cripps
Feb 7, 2014·Critical Reviews in Food Science and Nutrition·Rabia Ashraf, Nagendra P Shah
Oct 27, 2015·Critical Reviews in Food Science and Nutrition·Livia Bordalo TonucciHercia Stampini Duarte Martino
Nov 27, 2014·Scientific Reports·Matthew J BullEshwar Mahenthiralingam
Jan 8, 2015·Journal of Pediatric Gastroenterology and Nutrition·Ke WenLijuan Yuan
Feb 16, 2017·Clinical & Translational Immunology·Lieke Wj van den ElsenElizabeth E Forbes-Blom
Mar 27, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Anil Minocha
Apr 16, 2011·Inflammatory Bowel Diseases·Emil Rathsach PetersenNanna Ny Kristensen
Aug 9, 2017·The Pediatric Infectious Disease Journal·Tran Thi Hong ChauUNKNOWN Oxford-Vietnam Probiotics Study Group
Mar 18, 2011·The Cochrane Database of Systematic Reviews·David SinclairPatricia M Graves
Feb 28, 2016·Applied and Environmental Microbiology·Jeffrey P HymesTodd R Klaenhammer
Nov 26, 2013·Applied and Environmental Microbiology·Giselle Nobre CostaLucia Helena S Miglioranza

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