PMID: 1562Aug 1, 1975

Effects of several beta-blockers on blood pressure in the rat

Japanese Journal of Pharmacology
J YamamotoH Maekawa

Abstract

Effects of practolol, alprenolol and pindolol on blood pressure in the rat were studied. Also effects of these three beta-blocking agents on blood pressure and heart rate in spinal rats during adrenaline infusion were studied and compared with those of propranolol. The beta-blocking agents produced a sustained pressor action in the rat, and in the spinal rat infused with adrenaline. The magnitude of the pressor action induced by the beta-blockers was in the following order: pindolol larger than or equal to propranolol larger than or equal to alprenolol greater than practolol. Minimum doses of these beta-blockers required to cause a pressor action in the spinal rat infused with adrenaline were in the following order; practolol greater than alprenolol larger than or equal to propranolol larger than or equal to pindolol. The magnitude of the pressor action produced by the same dose of these beta-blockers and minimum doses of these beta-blockers required to cause a pressor action in the spinal rat infused with adrenaline seemed to be roughly proportional to their beta-receptor blocking activities. It was concluded that the minimum doses of these beta-blockers required to cause a pressor action and the magnitude of the pressor actio...Continue Reading

Related Concepts

Adrenergic beta-Antagonists
Alprenolol Hydrochloride
Diastolic Blood Pressure
Dose-Response Relationship, Drug
Medihaler-Epi
Right Atrial Structure
Pulse Rate
Myocardial Contraction
Visken
Dalzic

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