PMID: 6110470Feb 1, 1981Paper

Effects of severe dopamine depletion on dopamine neuronal impulse flow and on tyrosine hydroxylase regulation

Brain Research Bulletin
D C GermanP A SHORE

Abstract

Reserpine depletes dopamine (DA) levels and increases tyrosine hydroxylase (TH) activity in the rat corpus striatum. TH is activated not only by enhancement of DA neuronal impulse flow, but also by cessation of impulse flow. To assist in the understanding of the relative contribution of impulse flow to the regulation of TH activity in the DA depleted neuron, we examined the consequences of severe DA depletion on substantia nigra DA neuronal impulse flow and on in vivo TH activity in the rat corpus striatum. One day after reserpine or 30 min after the reversible reserpine-like compound, Ro4-1284, striatal DA levels were severely depleted and in vivo TH activity was enhanced about three-fold. DA depletion was found to significantly increase DA neuronal impulse flow. Although the DA neuron is firing faster than normal in the DA depleted rat, because there is no DA being released it is still not clear whether the elevation in TH activity is due to the enhancement of impulse flow or to the lack of DA at presynaptic receptor sites, or both. gamma-Butyrolactone (GBL), causes a cessation of DA neuronal impulse flow and activates TH by a presynaptic autoreceptor mechanism. GBL inhibited by over 50 percent the elevation in TH activity pr...Continue Reading

References

Jan 1, 1979·Journal of Neural Transmission·D C GermanP A Shore
Mar 29, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·B A McMillen, P A Shore

❮ Previous
Next ❯

Citations

Oct 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·O F Jenkins, D M Jackson
Jan 11, 1992·Journal of Neural Transmission. General Section·D E Dluzen, F T Kratko
Dec 15, 1989·Biochemical Pharmacology·C T Giambalvo
Jun 3, 1996·European Journal of Pharmacology·J L NeisewanderA N Sussman
Feb 13, 1999·European Journal of Pharmacology·S YehudaD I Mostofsky
Jul 9, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irene BrunkGudrun Ahnert-Hilger
May 1, 1983·Medical Hypotheses·F E Barr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.