Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep

Shock
Dirk M MaybauerDaniel L Traber

Abstract

This prospective, randomized, controlled experimental study looks at the effects on global and regional microvascular blood flow (RMBF) in an ovine model of septic shock after severe smoke inhalation injury. Sixteen sheep were randomized into two groups, a control group (no injury, n = 8) and a smoke/sepsis (SS) group (n = 8), which received an insufflation of 4 sets of 12 breaths of cotton smoke (<40 degrees C) followed by instillation of live Pseudomonas aeruginosa into both lung lobes, according to an established protocol. All sheep were mechanically ventilated with 100% oxygen, and fluid resuscitated with lactated Ringer's solution for the entire duration of the 24-h experimental period to maintain hematocrit at baseline (BL) levels. Healthy control animals were not subjected to the injury and received only 4 x 12 breaths of room air and instillation of the vehicle (normal saline). Blood flow was analyzed using colored microspheres. Control animals remained hemodynamically stable and had no statistical changes from BL in visceral or cerebral blood flow during the entire experimental period. All SS animals developed a hypotensive, hyperdynamic circulation, characterized by a significant increase in heart rate and cardiac out...Continue Reading

References

Jun 1, 1992·Critical Care Medicine·R C BoneW J Sibbald
Aug 15, 1990·Hospital Practice·F B Cerra
May 1, 1990·The American Review of Respiratory Disease·A D BerstenW J Sibbald
Jan 1, 1987·Annals of Surgery·K Z ShiraniA D Mason
Feb 1, 1986·The Journal of Trauma·P B ThompsonS Abston
Dec 1, 1984·The Journal of Trauma·David N HerndonLillian D Traber
Jun 1, 1994·Journal of Applied Physiology·J MeyerDaniel L Traber
Feb 1, 1996·Brain : a Journal of Neurology·G L DeferJ P Nguyen
Mar 4, 1997·Circulation·Donald W LandryJ A Oliver
Oct 23, 1997·Critical Care Medicine·V PollardDaniel L Traber
May 28, 1998·Burns : Journal of the International Society for Burn Injuries·C ShinG C Kramer
Sep 1, 2001·The New England Journal of Medicine·Donald W Landry, J A Oliver
Sep 6, 2001·Intensive Care Medicine·C TerborgJ Röther
Jan 17, 2002·The New England Journal of Medicine·E RiversEarly Goal-Directed Therapy Collaborative Group
Sep 28, 2002·Critical Care Medicine·Kazunori MurakamiDaniel L Traber
May 24, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Perenlei EnkhbaatarDaniel L Traber
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergStanislao Morgera
Dec 24, 2005·Shock·Daniel L TraberLillian D Traber

Citations

Jun 12, 2009·Der Anaesthesist·Marc O MaybauerDirk M Maybauer
May 16, 2007·Intensive Care Medicine·Marc O MaybauerDaniel L Traber
Dec 4, 2008·Critical Care Medicine·Matthias LangePerenlei Enkhbaatar
May 2, 2009·Journal of Applied Physiology·Matthias LangeHal K Hawkins
Feb 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Collette JonkamPerenlei Enkhbaatar
Nov 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Marc O MaybauerDaniel L Traber
Feb 13, 2016·Frontiers in Neurology·Judith BellapartJohn F Fraser
Jun 19, 2013·Burns : Journal of the International Society for Burn Injuries·Matthias LangePerenlei Enkhbaatar
Jun 1, 2012·Burns : Journal of the International Society for Burn Injuries·Matthias LangePerenlei Enkhbaatar
Feb 25, 2011·Burns : Journal of the International Society for Burn Injuries·Dirk M MaybauerDaniel L Traber
Jun 1, 2010·Burns : Journal of the International Society for Burn Injuries·Susumu YamashitaTaehyung Han
Jun 10, 2009·Burns : Journal of the International Society for Burn Injuries·P C FuchsN Pallua
Jul 9, 2010·Journal of the American Animal Hospital Association·Marc KentAlexander Delahunta
Nov 10, 2018·Intensive Care Medicine Experimental·Judith BellapartJohn F Fraser
Jun 26, 2007·Shock·Matthias LangeMartin Westphal

Related Concepts

Diastolic Blood Pressure
Pulse Rate
Lung
Microcirculation
Multiple Organ Failure
Nitrates
Nitrites
Respiratory Distress Syndrome, Adult
Endotoxic Shock
Smoke Inhalation Injury

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.