Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

Frontiers in Cellular Neuroscience
Ziyi WuPing Zhao

Abstract

Fetal exposure to general anesthetics may pose significant neurocognitive risks but methods to mitigate against these detrimental effects are still to be determined. We set out, therefore, to assess whether single or repeated in utero exposure to sevoflurane triggers long-term cognitive impairments in rat offspring. Since maternal exercise during pregnancy has been shown to improve cognition in offspring, we hypothesized that maternal treadmill exercise during pregnancy would protect against sevoflurane-induced neurotoxicity. In the first experiment, pregnant rats were exposed to 3% sevoflurane for 2 h on gestational (G) day 14, or to sequential exposure for 2 h on G13, G14 and G15. In the second experiment, pregnant rats in the exercise group were forced to run on a treadmill for 60 min/day during the whole pregnancy. The TrkB antagonist ANA-12 was used to investigate whether the brain-derived neurotrophic factor (BDNF)/TrkB/Akt signaling pathway is involved in the neuroprotection afforded by maternal exercise. Our data suggest that repeated, but not single, exposure to sevoflurane caused a reduction in both histone acetylation and BDNF expression in fetal brain tissues and postnatal hippocampus. This was accompanied by decrea...Continue Reading

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Citations

Apr 20, 2019·The Physician and Sportsmedicine·Paul D Loprinzi
Aug 15, 2020·Frontiers in Medicine·Lei ZhangHong Jiang
Jun 2, 2020·World Journal of Psychiatry·Anatoly E MartynyukJia-Qiang Zhang
Dec 2, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yong ZuoZhenhua Shi
Feb 19, 2021·Frontiers in Pharmacology·Xingyue LiPing Zhao
Jun 2, 2021·Brain Structure & Function·Simon GranakSaak V Ovsepian
Aug 18, 2020·Brain Research Bulletin·Fan YangHongtao Liu

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Methods Mentioned

BETA
histone acetylation
acetylation
immunoprecipitation

Software Mentioned

ImageJ
SPSS

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