Effects of sevoflurane on autonomic nerve activities controlling cardiovascular functions in rats

Journal of Anesthesia
M KurosawaA Sato

Abstract

Effects of different inspiratory concentrations of sevoflurane (fluorometyl-1,1,1,3,3,3,-hexafluoro-2-propylether) on blood pressure, heart rate and efferent activities of cardiac sympathetic, cardiac parasympathetic and renal sympathetic nerves were examined using rats either under the resting condition or during noxious mechanical stimulation of a hindpaw. Under the resting condition, an increase in the inspiratory concentration of sevoflurane from 2.1% to 4.2% gradually caused a decrease in blood pressure and heart rate. With the increase in the sevoflurane concentration, cardiac sympathetic nerve activity decreased, whereas renal sympathetic nerve and cardiac parasympathetic nerve activities did not change significantly. When noxious mechanical stimulation was applied to a hind-paw by pinching, blood pressure and heart rate, renal sympathetic and cardiac sympathetic nerve activities all increased at the 2.1% concentration of sevoflurane. The responses of these parameters were attenuated at the 3.1% concentration of sevoflurane and almost disappeared at the 4.2% concentration. Cardiac parasympathetic nerve activity did not change significantly during the pinching stimulation throughout the 2.1-4.2% concentration increase.

Citations

May 1, 1995·Acta Anaesthesiologica Scandinavica·O TakahataH Ogawa
Oct 3, 2012·Autonomic Neuroscience : Basic & Clinical·Sae UchidaHarumi Hotta
Sep 8, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R StoyekFrank M Smith
Dec 1, 1995·Anesthesia and Analgesia·T J EbertM Muzi
Mar 7, 2000·Anesthesia and Analgesia·S A Kozek-LangeneckerM Semsroth
Mar 1, 1998·Journal of Anesthesia·Kazu-Ichi Yoshida, Akiyoshi Ohsawa
Jul 1, 2017·Anesthesiology Research and Practice·Koichi ShimoKenji Shigemi

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