Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca2+ release in rat skeletal muscle

Journal of Natural Medicines
Noriko KaifuchiYoshio Kase

Abstract

Shakuyakukanzoto (SKT) is a kampo medicine composed of equal proportions of Glycyrrhizae radix (G. radix) and Paeoniae radix (P. radix). A double-blind study reported that SKT significantly ameliorated painful muscle cramp in cirrhosis patients without the typical severe side effects of muscle weakness and central nervous system (CNS) depression. Previous basic studies reported that SKT and its active components induced relaxation by a direct action on skeletal muscle and that SKT did not depress CNS functions; however, why SKT has a lower incidence of muscle weakness remains unknown. In the present study, we investigated which components are absorbed into the blood of rats after a single oral administration of SKT to identify the active components of SKT. We also investigated the effects of SKT and its components on the twitch contraction induced by physiological Ca(2+) release. Our study demonstrated that SKT and five G. radix isolates, which are responsible for the antispasmodic effect of SKT, did not inhibit the twitch contraction in contrast to dantrolene sodium, a direct-acting peripheral muscle relaxant, indicating that the mechanisms of muscle contraction of SKT and dantrolene in skeletal muscle differ. These findings s...Continue Reading

References

Apr 1, 1990·The Journal of Physiology·G D Lamb, D G Stephenson
Feb 1, 1989·The American Journal of Physiology·T OhtaA Ohga
Apr 1, 1981·British Journal of Pharmacology·G C Leslie, N J Part
Jun 1, 1995·The Journal of Clinical Endocrinology and Metabolism·H KatoM Kobayashi
Jan 28, 1993·Nature·M J Berridge
Dec 22, 2004·The Journal of Biological Chemistry·Shigeki KobayashiNoriaki Ikemoto
Apr 16, 2005·The Journal of Pharmacology and Experimental Therapeutics·Yingfan ZhangMartin F Schneider
Jun 17, 2005·Anaesthesia and Intensive Care·W AlkhazrajyW J Russell
Nov 30, 2005·Journal of Pharmacological Sciences·Yuji OmiyaShuichi Takeda
Feb 13, 2007·Journal of the American Society for Mass Spectrometry·Li LiChuan Li
Oct 8, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Tsutomu YoshidaHisayoshi Fujiwara
Apr 25, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Hiroyuki KinoshitaFumiatsu Yakushiji
May 21, 2011·European Journal of Pain : EJP·Keiko K LeeHiroyuki Kobayashi
Jun 8, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cheng XiangMin Ye

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Citations

Jun 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xue DingYang Yang
Nov 11, 2017·Acute Medicine & Surgery·Hajime NakaeToshiko Igarashi
Jun 4, 2020·Journal of General and Family Medicine·Koshi OtaAkira Takasu
Dec 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee

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