Effects of shear force on intervertebral disc: an in vivo rabbit study

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Dong-Dong XiaJun Tan

Abstract

A new in vivo rabbit model was developed to investigate the effects of shear force on intervertebral disc (IVD). Japanese white rabbits (n = 38) were used for this study. The L4/5 discs in Group A (n = 10) were subjected to a constant shear force (50 N) using a custom-made external loading device for 1 month; in Group B (n = 10) for 2 months; whereas in Group C (n = 10), loading device was attached to the spine but the discs remained unloaded. Group D (n = 8) was a non-operated intact control group. After loading, the loading devices were taken out and the animals were given X-ray and MRI examination. After X-ray and MRI examination, the animals were euthanized for histological analysis. After 1 and 2 months of loading, radiographic findings showed significant disc height narrowing in L4/5 discs of the animals in loading groups, and slight lumbar spondylolisthesis in some animals of Group B. MRI showed a significant decrease in nucleus pulposus (NP) area and signal intensity from T2-weighted images. Histologically, loss of normal NP cells and disorganization of the architecture of the annulus occurred, and proteoglycan stain decreased. The results of this study suggest that disc degeneration can be induced by hyper-physiologica...Continue Reading

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Citations

May 30, 2019·Journal of Sport Rehabilitation·Gakuto KitamuraNoriaki Ichihashi
Oct 5, 2019·Oxidative Medicine and Cellular Longevity·Zengjie ZhangXiaolei Zhang

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