Effects of shenque moxibustion on behavioral changes and brain oxidative state in apolipoprotein e-deficient mice

Evidence-based Complementary and Alternative Medicine : ECAM
Juntian LiuLixing Lao

Abstract

Purpose. To determine whether moxibustion influences the learning and memory behavior of ApoE-/- male mice, and investigate the mechanism of moxibustion on the alteration of oxidized proteins (glial fibrillary acidic protein, β-amyloid) in hippocampus. Methods. Thirty-three ApoE-/- mice were randomly divided into 3 groups (n = 11/group): moxibustion, sham moxibustion, and no treatment control. Wild-type C57BL/6 mice (n = 13) were used for normal control. Moxibustion was performed with Shenque (RN8) moxibustion for 20 minutes per day, 6 days/week for 12 weeks. In sham control, the procedure was similar except burning of the moxa stick. Behavioral tests (step-down test and Morris water maze task) were conducted in the 13th week. The mice were then sacrificed and the tissues were harvested for immune-histochemical staining. Results. In the step-down test, the moxibustion group had shorter reaction time in training record and committed less mistakes compared to sham control. In immune-histochemical study, the moxibustion group expressed lower level of GFAP and less aggregation of β-amyloid in the hippocampus than the sham control. Conclusion. Our findings suggest that moxibustion may enhance learning capability of ApoE-/- mice. The...Continue Reading

References

Sep 1, 1993·Neurobiology of Aging·N R NicholsC E Finch
Jun 23, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·I VeinbergsE Masliah
May 23, 2000·Journal of Neurochemistry·M AksenovW R Markesbery
Oct 10, 2003·Journal of Neuropathology and Experimental Neurology·Tamas ReveszJanice L Holton
Mar 3, 2004·Molecular Interventions·K R BalesS M Paul
Feb 15, 2005·Neurobiology of Aging·Jennifer RobertsonJacob Raber
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrey Y Abramov, Michael R Duchen
Jan 13, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·G SamandourasO Ansorge
Jan 25, 2006·Neurology·Yadong Huang
Feb 22, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hong ZhangCheng Peng
Aug 14, 2012·Neurobiology of Aging·Yifat SegevKobi Rosenblum
Jan 15, 2013·International Journal of Molecular Medicine·Sun Haeng ParkHwa Kyoung Shin
Feb 27, 2013·Pharmacology, Biochemistry, and Behavior·Anahita Torkaman-BoutorabiMohammad-Reza Zarrindast
Jul 9, 2013·BMC Complementary and Alternative Medicine·Xiao-Hui ChangGuo-Zhu Han
Aug 27, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·E Orta-SalazarS Díaz-Cintra
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tracy L HagemannAlbee Messing
Jan 23, 2014·Biochemical Pharmacology·Rudy J Castellani, George Perry
Mar 22, 2014·Neuroscience Bulletin·Evan DoreyWandong Zhang
Sep 28, 2014·Brain Structure & Function·Thibault CholvinJean-Christophe Cassel

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Citations

Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Lue HaBaixiao Zhao
Mar 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Hao WangZhao Baixiao
Nov 13, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoyu XuHongning Liu

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Methods Mentioned

BETA
lipidation

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