PMID: 1210225Jan 1, 1975Paper

Effects of shifts in hemoglobin-oxygen affinity during hypoxia

Vox Sanguinis
P W RandM Lovell

Abstract

To investigate the possibility that the influence of hemoglobin-oxygen affinity on tissue oxygenation may be reversed in severe hypoxia, 16 anesthetized rabbits with chronically-implanted tissue oxygen electrodes were ventilated with 12% oxygen and subjected to 100 ml exchange transfusions with high, low, or normal affinity rabbit blood. Despite the widely divergent in vivo P50 values produced, significant differences in tissue oxygen levels were not observed among the three groups following exchange transfusions. During subsequent normoxia, more complete recovery of tissue oxygen was apparent in the low affinity group. This study emphasizes the need for further definition of the influence of hemoglobin-oxygen affinity on the functions of individual organs.

References

Oct 1, 1973·The Journal of Clinical Investigation·T E RiggsC A Guenter
Feb 24, 1972·The New England Journal of Medicine·C A Finch, C Lenfant
Nov 1, 1973·British Journal of Haematology·A J Bellingham, A J Grimes
Jun 1, 1973·Journal of Applied Physiology·P W RandW H Austin
Nov 1, 1973·The Journal of Clinical Investigation·R D WoodsonJ C Detter
Jan 1, 1974·Journal of Applied Physiology·J M Norton, P W Rand
Jun 18, 1970·The New England Journal of Medicine·H F Bunn, J H Jandl
Nov 1, 1957·The American Journal of Medicine·H MONTGOMERY

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Citations

Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·J M Norton, R P Smith
Nov 1, 1976·Canadian Anaesthetists' Society Journal·M Kerri-Szanto

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