PMID: 9530993Apr 8, 1998Paper

Effects of Sho-saiko-to on the pharmacokinetics and pharmacodynamics of tolbutamide in rats

The Journal of Pharmacy and Pharmacology
N NishimuraK Iwamoto

Abstract

Although Sho-saiko-to (Xiao Chai Hu Tang), a major Chinese traditional medicine, is frequently prescribed with other synthetic or biotechnological drugs for the treatment of various chronic diseases, there is a dearth of information about interactions between sho-saiko-to and co-administered drugs. This paper reports the effects of Sho-saiko-to on the pharmacokinetics and glucose responses of a sulphonylurea hypoglycaemic agent, tolbutamide, after their oral administration in rats. After oral administration of tolbutamide (50 mg kg(-1)) with or without Sho-saiko-to extract powder (300 mg kg(-1)) to male Sprague-Dawley rats cannulated in the jugular vein, plasma tolbutamide and glucose levels were periodically measured. Co-administration of Sho-saiko-to tended to elevate the plasma tolbutamide concentration in the absorption phase. A two-compartment lag-time model was found to describe the plasma tolbutamide concentration-time data. The maximum concentration of tolbutamide was significantly increased and time to reach the maximum concentration was reduced to about 70% by co-administration with Sho-saiko-to. There was no significant change in area under the curve or in the elimination half-life of tolbutamide. The extent of the l...Continue Reading

References

Jan 1, 1977·Drugs·J M Hansen, L K Christensen
Jan 1, 1975·Journal of Pharmaceutical Sciences·R A Upton
Jan 1, 1992·European Journal of Clinical Pharmacology·K T Kivistö, P J Neuvonen
Jan 1, 1991·European Journal of Clinical Pharmacology·K T Kivistö, P J Neuvonen

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Citations

Oct 12, 2000·Journal of Ethnopharmacology·A T BorchersM E Gershwin
Apr 18, 2001·Biological & Pharmaceutical Bulletin·N NishimuraK Iwamoto
Feb 24, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·N NishimuraK Iwamoto
Apr 2, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Nobuhiro Nishimura
Mar 15, 2003·Drug Metabolism Reviews·Shufeng ZhouJames W Paxton

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