Effects of short- and long-term sympathectomy on vasoconstrictor responses of the rat mesenteric arterial bed

British Journal of Pharmacology
V Ralevic, G Burnstock

Abstract

1. The effects of short- and long-term sympathectomy were evaluated on vasoconstrictor function of constantly perfused mesenteric arterial beds isolated from rats: the effects of short-term sympathectomy were assessed at 3 and 8 days after 6-hydroxydopamine (6-OHDA) treatment of adult rats; the effects of long-term sympathectomy were assessed in adult rats treated at youth with guanethidine. 2. The relative degree of residual sympathetic innervation of the mesenteric arterial preparations was assessed by responses to electrical field stimulation (EFS; 16 Hz, 1 ms, 90 V, 30 s). Control responses were 95.6 +/- 3.9 mmHg (n = 35). Responses after sympathectomy were: 3 days after 6-OHDA, 2.9 +/- 0.9 mmHg (n = 15) < 8 days after 6-OHDA, 14.1 +/- 2.1 mmHg (n = 14) < guanethidine, 21.1 +/- 4.1 mmHg (n = 16). 3. Three days after 6-OHDA treatment there was an increase in the sensitivities of response to vasopressin and endothelin, producing leftward shifts of the dose-response curves of 0.66 +/- 0.11 and 0.88 +/- 0.13 log units respectively (n = 7-11), and a small increase in sensitivity of responses to noradrenaline (NA) and ATP. The maximal response to 5-hydroxytryptamine (5-HT) was increased. In contrast, there was a decrease in maxim...Continue Reading

References

Aug 1, 1977·Circulation Research·O Aprigliano, K Hermsmeyer
Aug 1, 1977·Journal of Neurocytology·J W Heath, G Burnstock
Apr 11, 1976·British Journal of Pharmacology·O Carrier, R K Hester
Oct 4, 1989·European Journal of Pharmacology·J S Lacroix, J M Lundberg
Jan 1, 1989·Pharmacology & Therapeutics·J A Angus, T M Cocks
Nov 1, 1989·The American Review of Respiratory Disease·R D Bevan
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
May 7, 1982·European Journal of Pharmacology·Y WatanabeH Yoshida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.