Effects of short term and long term Extremely Low Frequency Magnetic Field on depressive disorder in mice: Involvement of nitric oxide pathway

Life Sciences
Alireza Madjid AnsariKeivan Majidzadeh-A

Abstract

Previous reports on the possible effects of Extremely Low Frequency Magnetic Fields (ELF MF) on mood have been paradoxical in different settings while no study has yet been conducted on animal behavior. In addition, it was shown that ELF MF exposure makes an increase in brain nitric oxide level. Therefore, in the current study, we aimed to assess the possible effect(s) of ELF MF exposure on mice Forced Swimming Test (FST) and evaluate the probable role of the increased level of nitric oxide in the observed behavior. Male adult mice NMRI were recruited to investigate the short term and long term ELF MF exposure (0.5mT and 50Hz, single 2h and 2weeks 2h a day). Locomotor behavior was assessed by using open-field test (OFT) followed by FST to evaluate the immobility time. Accordingly, NΩ-nitro-l-arginine methyl ester 30mg/kg was used to exert anti-depressant like effect. According to the results, short term exposure did not alter the immobility time, whereas long term exposure significantly reduces immobility time (p<0.01). However, it was revealed that the locomotion did not differ among all experimental groups. Short term exposure reversed the anti-depressant like effect resulting from 30mg/kg of NΩ-nitro-l-arginine methyl ester ...Continue Reading

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Citations

May 30, 2019·Toxicology and Industrial Health·Rezvan ZendehdelZahra Panjali
Apr 27, 2018·International Journal of Occupational Safety and Ergonomics : JOSE·Rajitha Kawshalya Mailan Arachchige DonSeung-Cheol Hong

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