Effects of short-term and prolonged infusions of somatostatin on endocrine pancreas, body weight and food intake in rats

Acta Physiologica Scandinavica
P E LinsS Efendić

Abstract

Infusion of cyclic somatostatin (700 mg/kg/min) for 4 h in rat fed and libitum suppressed basal insulin but not glucagon release. It was accompanied by hypoglycemia during the first hour whereas, at the end of the infusion, hyperglycemia was present. The same dose of somatostatin applied 60 min prior to and during a 30 min load of glucose or arginine significantly inhibited their effects on insulin and glucagon release. In contrast, when this dose of somatostatin was given during a 24 h period by the i.v. route it did not inhibit glucose induced insulin release though circulating somatostatin levels were constantly and markedly elevated. Furthermore, in rats continuously infused with somatostatin for 4 days, no effect was found either on plasma concentrations of glucose, insulin, glucagon, growth hormone and cyclic AMP, or on body weight gain, food consumption or water intake. The pancreases of these animals showed normal concentrations of insulin and glucagon and a normal nuclear area of D-cells. Our experiments demonstrate that, in short-term experiments in rats, somatostatin influences insulin and glucagon release as well as glucose homeostasis. Furthermore, they suggest that during prolonged i.v. administration of somatosta...Continue Reading

References

Sep 1, 1978·Metabolism: Clinical and Experimental·S EfendicR Luft
Aug 1, 1978·Acta Endocrinologica·S EdénO Isaksson
Jan 1, 1978·Scandinavian Journal of Gastroenterology·C JohanssonR Luft
Sep 1, 1978·Metabolism: Clinical and Experimental·A ArimuraC Meyers
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Dec 1, 1960·Acta Endocrinologica·C HELLERSTROEM, B HELLMAN
Jan 1, 1962·Zeitschrift für Zellforschung und mikroskopische Anatomie·B PETERSSONB HELLMAN
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE

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Citations

Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen C WoodsWolfgang Langhans
Sep 1, 1982·Acta Physiologica Scandinavica·J WareG Nylander
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J MorissetJ Bourassa

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