Effects of short-term dutasteride and Serenoa repens on perioperative bleeding and microvessel density in patients undergoing transurethral resection of the prostate

Scandinavian Journal of Urology and Nephrology
Altug TuncelAli Atan

Abstract

OBJECTIVE. To evaluate the effects of short term use of dutasteride and Serenoarepens before transurethral resection of the prostate (TURP) on the amount of intraoperative blood loss and microvessel density (MVD) of prostatic stromal and suburethral tissues in the patients with benign prostatic hyperplasia. The study involved 75 male patients who planned to have a TURP. The patients were randomly divided into three groups. The control group comprised 21 patients. Group 2 comprised 27 patients who used dutasteride 5 mg/day, and group 3 comprised 27 patients who used S. repens 160 mg/day for 5 weeks before the operation. The amount of intraoperative haemorrhage was calculated. Total blood loss, total blood loss/time, total blood loss/weight of resected tissue and total blood loss/weight/time were calculated for each patient and all were recorded. Sections from the prostatic stromal and suburethral tissues were examined for suburethral and prostatic MVD. The total amount of intraoperative blood loss, total blood loss/time, total blood loss/weight of resected tissue, total blood loss/weight/time, serum haemoglobin level change, prostatic MVD and suburethral MVD of the groups were compared. No significant statistical differences wer...Continue Reading

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Citations

Oct 18, 2011·International Urology and Nephrology·Alejandro Lira-DaleIvan Delgado-Enciso
Oct 5, 2011·Therapeutic Advances in Urology·Petrisor GeavleteBogdan Geavlete
Feb 25, 2018·The Kaohsiung Journal of Medical Sciences·Run-Qi GuoBai-Nian Pan
Aug 17, 2011·Nature Reviews. Urology·Liam E KavanaghUNKNOWN Medscape
Dec 4, 2010·Current Opinion in Urology

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