PMID: 9194764Jun 1, 1997Paper

Effects of short-term hormone replacement therapies on low-density lipoprotein metabolism in cynomologus monkeys

Arteriosclerosis, Thrombosis, and Vascular Biology
J D WagnerM R Adams

Abstract

Estrogen replacement therapy reduces the risk of coronary heart disease in women and decreases the extent of atherosclerosis in monkeys. In our previous studies, estrogen treatment decreased arterial LDL degradation and accumulation, thus indicating one mechanism by which estrogen inhibits the progression of atherosclerosis. The influence of progestins on these processes remains nuclear. The objective of this study was to determine the effects of oral estrogen (conjugated equine estrogens) and progestin (medroxyprogesterone acetate) alone or in combination on arterial LDL metabolism after 12 weeks of atherogenic stimulus. This relatively short period of treatment was chosen to determine effects on arterial LDL metabolism before substantial subendothelial macrophage accumulation. In contrast to previous studies (16 to 18 weeks of treatment), when macrophages were present in the intima, neither estrogen nor progestin (nor their combination) had any effect on any index of arterial LDL metabolism. These results suggest that estrogen may preferentially reduce LDL metabolism in macrophages with little effect on cells of the normal artery. In contrast to arterial LDL metabolism, hepatic LDL uptake was significantly increased in animal...Continue Reading

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Citations

Sep 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Kylie KavanaghJanice D Wagner
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·W B StrawnC M Ferrario
Nov 14, 1998·Annals of Medicine·M R Taskinen
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A E MullickJ C Rutledge
Feb 22, 2001·American Journal of Physiology. Renal Physiology·R K Dubey, E K Jackson
Nov 26, 2002·Endocrinology·Jeffrey B Hodgin, Nobuyo Maeda
Mar 2, 2021·Endocrinology·Tharini SivasubramaniyamMinna Woo
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·George I Gorodeski
Apr 29, 1998·Metabolism: Clinical and Experimental·P L ColvinM G Sorci-Thomas

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