Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults

The Journal of Clinical Endocrinology and Metabolism
T BiandaC Schmid

Abstract

Administration of insulin-like growth factor-I (IGF-I) or growth hormone (GH) is known to stimulate bone turnover and kidney function. To investigate the effects of IGF-I and GH on markers of bone turnover, eight adult GH-deficient patients (48 +/- 14 yr of age) were treated with IGF-I (5 micrograms/kg/h in a continuous s.c. infusion) and GH (0.03 IU/kg/daily s.c. injection at 2000 h) in a randomized cross-over study. We monitored baseline values for three consecutive days before initiating the five-day treatment period, as well as the wash-out period of ten weeks. Serum osteocalcin, carboxyterminal and aminoterminal propeptide of type I procollagen (PICP and PINP, respectively) increased significantly within 2-3 days of both treatments (P < 0.02) and returned to baseline levels within one week after the treatment end. The changes in resorption markers were less marked as compared with formation markers. Total 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) rose significantly, whereas PTH and calcium levels remained unchanged during either treatment. Because the rapid increase in markers of bone formation was not preceded by an increase in resorption markers, IGF-I is likely to stimulate bone formation by a direct effect on osteob...Continue Reading

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Citations

Dec 17, 2009·International Journal of Endocrinology·Jessica A Alvarez, Ambika Ashraf
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T Bianda, C Schmid
Mar 28, 2002·Pharmacology & Therapeutics·M A Rodríguez-Martínez, E C García-Cohen
Nov 11, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Gérard GuillaumeMaurice Audran
Nov 21, 2008·Journal of Internal Medicine·O GunnarssonG Sigurdsson
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sebastien ElisShoshana Yakar
Jun 25, 2013·Clinical Endocrinology·Pietro AmeriDiego Ferone
Nov 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Thor Ueland
Aug 2, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Christoph SchmidPeter Wiesli
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pedro IglesiasRafael Selgas
Mar 20, 2019·Journal of Translational Medicine·Susanna EspositoLaura Penta

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