Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle

Journal of Dairy Science
H KhatibRicky L Monson

Abstract

Infertility is a major cause of dairy cow culling and economic loss. Signal transducer and activator of transcription (STAT) proteins are transcription factors that play an important role in fertility and early embryonic development, among many other functions. Previous studies have reported the association of several genes from the JAK/STAT signaling pathway with fertility traits in cattle. The STAT1 and STAT3 genes are members of this pathway and are known to interact with each other by forming a heterodimer complex that enters the nucleus and controls expression of specific genes. Thus, the objective of this study was to investigate the effects of the interactions between polymorphisms in these genes on fertilization and early embryonic survival rates using an in vitro fertilization system. A total of 7,519 oocytes, collected from 445 ovaries, were exposed to sperm and a total of 5,075 embryos were produced. Fertilization rate was calculated as the number of cleaved embryos at 48 h post-fertilization out of the total number of oocytes exposed to sperm. Early embryonic survival rate of embryos was calculated as the number of blastocysts on d 7 of development out of the total number of embryos cultured. Effects of ovary genoty...Continue Reading

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Citations

May 8, 2015·Autophagy·Liangkun YouWeidong Han
Mar 29, 2018·Cellular & Molecular Biology Letters·Michaela GaloczovaBorivoj Vojtesek
Jun 21, 2019·Current Topics in Medicinal Chemistry·Yang Sheng HuXin Hua Liu
Jan 14, 2020·Zygote : the Biology of Gametes and Early Embryos·Nasser GhanemDawit Tesfaye
Aug 29, 2018·International Journal of Molecular Sciences·Adolf A AmmahEveline M Ibeagha-Awemu
Oct 23, 2014·Tropical Animal Health and Production·Tingxian DengXianwei Liang
Jan 10, 2012·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S M WatersM P Mullen
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sepideh MirzaeiHaroon Khan
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Vittoria Lucia BarileOlimpia Barbato

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