Effects of sildenafil citrate on defibrillation efficacy

Journal of Cardiovascular Electrophysiology
Krekwit ShinlapawittayatornNipon Chattipakorn

Abstract

Although fatal arrhythmia and sudden death have been reported in patients taking sildenafil citrate, its effect on defibrillation efficacy has not been investigated. The aim of this study was to test the hypothesis that sildenafil citrate increases the shock strength required to successfully defibrillate during ventricular fibrillation (VF). A total of 26 pigs (20-25 kg) were randomly assigned into three groups. In each group, the defibrillation threshold (DFT) was determined at the beginning of the study using a three-reversal up/down protocol. Each shock (RV-SVC, biphasic) was delivered after 10 seconds of VF. Group 1 (n = 10) received 50 mg and group 2 (n = 10) received 100 mg of sildenafil citrate intravenously at a rate of 2 mL/minute for 50 minutes. Group 3 (n = 6) received 100 mL of saline intravenously at the same rate as in group 1. The DFT was determined again after the drug (drug-DFT) and saline (saline-DFT) administration. For 100-mg sildenafil citrate infusion, the DFT (483 +/- 39 V, 18 +/- 3 J) was significantly (P < 0.003 and P < 0.01, respectively) higher than the control-DFT (407 +/- 123 V, 13 +/- 7 J). This sildenafil citrate infusion increased the DFT approximately 19% by voltage, and approximately 38% by tot...Continue Reading

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Citations

Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Natnicha KanlopNipon Chattipakorn
Apr 28, 2007·Pacing and Clinical Electrophysiology : PACE·Charles D SwerdlowPaul J Degroot
Apr 18, 2012·Congestive Heart Failure·Amit VarmaMichael L Hess
Jul 13, 2006·Circulation·Mark A Wood, Kenneth A Ellenbogen
Apr 29, 2006·Journal of Cardiovascular Electrophysiology·Peter R Kowey, Gan-Xin Yan
Oct 23, 2008·Expert Review of Cardiovascular Therapy·Eric R UyguancoJohn Kassotis

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