Effects of silica on human lung fibroblast in culture

The Science of the Total Environment
G ArcangeliG Giuliano

Abstract

Silica has been reported to directly stimulate cellular proliferation of human lung fibroblasts, and silica-treated macrophage supernatants induce fibroblast proliferation and some of their biosynthetic activities. Alveolar macrophages produce increased amount of tumour necrosis factor alpha (TNF-alpha) and transforming growth factor beta (TGF-beta). Lung fibroblasts are producers of interleukin-6 (IL-6). We investigated the capacity of lung fibroblasts obtained from normal and silicosis subjects to elaborate IL-6 in response to TNF-alpha and to TGF-beta. Our data show that TNF-alpha and TGF-beta are able to stimulate the proliferation of human lung fibroblasts in culture, to increase the collagen production of the cells and are both able to increase IL-6 production by lung fibroblasts of patients with silicosis. We hypothesise that silica is able to stimulate lung fibroblast both directly, increasing the cell proliferation, and indirectly stimulating the release of factors (as TNF-alpha and TGF-beta) from activated alveolar macrophages, that are able to increase proliferative and biosynthetic activities of fibroblast.

References

Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·R P PhippsM E Felch
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·D VanhéeA B Tonnel
Oct 1, 1994·American Journal of Respiratory Cell and Molecular Biology·B E LehnertM D Englen
Apr 1, 1994·The European Respiratory Journal·J F MornexD Ecochard

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Citations

Sep 23, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M GulumianJ Murray
Jul 12, 2008·American Journal of Respiratory Cell and Molecular Biology·Yutong ZhaoViswanathan Natarajan
Dec 8, 2004·Environmental Health Perspectives·K Murali Krishna RaoVince Castranova
Feb 11, 2015·British Journal of Pharmacology·P G TrentinP M R Silva
May 25, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ji-Ung ParkSukwha Kim
May 13, 2008·Journal of Fish Diseases·R G ZanoniM Prearo
Oct 3, 2020·Inhalation Toxicology·Kaio Cezar Rodrigues SalumFabiana Barzotto Kohlrausch
Nov 30, 2019·Experimental and Therapeutic Medicine·Pingheng ZhangRuikai Zong
Aug 8, 2021·International Journal of Molecular Sciences·Shiyi Tan, Shi Chen

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