Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets

PloS One
Jorge A Santos-LópezFrancisco J Sánchez-Muniz

Abstract

Pork is an essential component of the diet that has been linked with major degenerative diseases and development of non-alcoholic steatohepatitis (NASH). Previous studies have. Previous studies have demonstrated the in vitro antioxidant activity of silicon (Si). Furthermore, when Si is added to restructured pork (RP) strongly counterbalances the negative effect of high-cholesterol-ingestion, acting as an active hypocholesterolemic and hypolipemic dietary ingredient in aged rats. This study was designed to evaluate the effects of Si vs hydroxytyrosol (HxT) RP on liver antioxidant defense in aged rats fed cholesterol-enriched high saturated/high cholesterol diets as a NASH model. Four diets were prepared: Control RP diet (C) with non-added cholesterol; Cholesterol-enriched high-saturated/high-cholesterol control RP diet (CHOL-C) with added cholesterol and cholic acid; Si- or HxT-RP cholesterol-enriched high-saturated/high-cholesterol diets (CHOL-Si and CHOL-HxT). Groups of six male Wistar rats (1-yr old) were fed these modified diets for eight weeks. Total cholesterol, hepatosomatic index, liver Nrf2 and antioxidant (CAT, SOD, GSH, GSSG, GR, GPx) markers were determined. Both CHOL-Si and CHOL-HxT diets enhanced the liver antioxid...Continue Reading

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Citations

Dec 14, 2016·Biological Trace Element Research·Małgorzata KiełczykowskaJoanna Kocot
Mar 16, 2017·Journal of Medicinal Food·Jorge Arturo Santos-LópezFrancisco José Sánchez-Muniz
Jan 7, 2017·Journal of Alzheimer's Disease : JAD·María José González-MuñozFrancisco J Sánchez-Muniz
Jul 5, 2019·British Journal of Pharmacology·Francesco VisioliJoao Tomé-Carneiro
Jul 13, 2019·Nutrients·Francisco José Sánchez-MunizMaría José González-Muñoz
Apr 17, 2020·Nutrition Reviews·João Tomé-CarneiroAlberto Dávalos
Sep 16, 2020·Antioxidants·Lorena Martínez-ZamoraGema Nieto
Feb 13, 2021·Advances in Nutrition·Adrián Macho-GonzálezFrancisco J Sánchez-Muniz

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

SPSS Statistics

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