Effects of silodosin and naftopidil on the distal ureter and cardiovascular system in anesthetized dogs: comparison of potential medications for distal ureteral stone passage

The Journal of Urology
Shinya KobayashiKenjiro Kohri

Abstract

We compared the effects of the selective alpha(1A)-adrenoceptor antagonist silodosin and the selective alpha(1D)-adrenoceptor antagonist naftopidil on intraureteral pressure in anesthetized dogs and evaluated their uroselectivity. Using anesthesia the effects of silodosin and naftopidil were evaluated by the phenylephrine induced increase in intravesical ureteral pressure and on blood pressure. Each drug was administered intravenously in progressively increasing doses. The dose of each alpha(1)-adrenoceptor antagonist at which mean blood pressure was decreased by 15% (ED(15)) and the dose at which the phenylephrine induced increase in intravesical ureteral pressure was suppressed by 50% (ID(50)) were measured and uroselectivity was calculated as ED(15)/ID(50). Silodosin dose dependently suppressed the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 2.5 microg/kg) but decreased mean blood pressure only at higher doses (ED(15) 143.4 microg/kg). In contrast, naftopidil decreased mean blood pressure (ED(15) 280.7 microg/kg) at the same doses as those that decreased the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 225.1 microg/kg). Silodosin uroselectivity was markedly higher than...Continue Reading

References

Jun 1, 1987·The Tohoku Journal of Experimental Medicine·T MoritaS Tsuchida
Jun 23, 1998·Lancet·C Y Pak
Oct 3, 2006·Lancet·John M HollingsworthBrent K Hollenbeck
Feb 14, 2007·The Journal of Urology·J Kellogg ParsonsCharles Lakin
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasunori ItohKenjiro Kohri
Nov 2, 2007·Urological Research·Hyoung Keun ParkByoung Kwon Kim

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Citations

Dec 14, 2018·Advances in Therapy·Luca VillaFrancesco Montorsi

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