Effects of Silymarin, Glycyrrhizin, and Oxymatrine on the Pharmacokinetics of Ribavirin and Its Major Metabolite in Rats

Phytotherapy Research : PTR
Sha LiaoZhenqing Zhang

Abstract

The herb-derived compounds silymarin, glycyrrhizin, and oxymatrine are widely used to treat chronic hepatitis C virus infections in China. They are often prescribed in combination with ribavirin, which has a narrow therapeutic index. We investigated the influence of these compounds on ribavirin pharmacokinetics following concurrent administration at the human dose in rats. Pharmacokinetic parameters were determined in rats following oral (p.o.) administration of ribavirin (30 mg/kg) with or without silymarin (40 mg/kg, p.o.), glycyrrhizin (15 mg/kg, intraperitoneal [i.p.]), or oxymatrine (60 mg/kg, p.o.). Compared with the animals in ribavirin group, silymarin significantly decreased the area under the plasma concentration-time curve (AUC0-t ) and the peak plasma concentration (Cmax ) of ribavirin and ribavirin base by 31.2-44.5% and 48.9-50.0%, respectively. Glycyrrhizin significantly decreased the Cmax and AUC0-t of both ribavirin and its metabolite by 35.3-37.6% and 38.6-39.8%, respectively. However, silymarin or glycyrrhizin did not change the ribavirin metabolite/parent ratios of the AUC and Cmax . Oxymatrine did not induce significant changes in ribavirin concentration, but it significantly decreased the Cmax (26.6%) and ...Continue Reading

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Citations

Jan 27, 2017·Phytotherapy Research : PTR·Aline Maria StolfAlexandra Acco
Aug 24, 2017·Phytotherapy Research : PTR·Somayeh NazariHossein Hosseinzadeh
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying LiZhan-Jun Dong
Oct 27, 2018·Frontiers in Veterinary Science·Begum Yurdakok-DikmenAyhan Filazi
Oct 16, 2019·Current Medicinal Chemistry·Kun ChenHai-Liang Zhu

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