Effects of simulated microgravity on arterial nitric oxide synthase and nitrate and nitrite content

Journal of Applied Physiology
Jin MaRalph E Purdy

Abstract

The aim of the present work was to investigate the alterations in nitric oxide synthase (NOS) expression and nitrate and nitrite (NOx) content of different arteries from simulated microgravity rats. Male Wistar rats were randomly assigned to either a control group or simulated microgravity group. For simulating microgravity, animals were subjected to hindlimb unweighting (HU) for 20 days. Different arterial tissues were removed for determination of NOS expression and NOx. Western blotting was used to measure endothelial NOS (eNOS) and inducible NOS (iNOS) protein content. Total concentrations of NOx, stable metabolites of nitric oxide, were determined by the chemiluminescence method. Compared with controls, isolated vessels from simulated microgravity rats showed a significant increase in both eNOS and iNOS expression in carotid arteries and thoracic aorta and a significant decrease in eNOS and iNOS expression of mesenteric arteries. The eNOS and iNOS content of cerebral arteries, as well as that of femoral arteries, showed no differences between the two groups. Concerning NOx, vessels from HU rats showed an increase in cerebral arteries, a decrease in mesenteric arteries, and no change in carotid artery, femoral artery and tho...Continue Reading

References

Jun 1, 1992·Journal of Applied Physiology·K S McDonaldR H Fitts
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Oct 1, 1991·Journal of Clinical Pharmacology·S L MulvaghM W Bungo
Apr 1, 1989·The American Journal of Physiology·B L LangilleF W Keeley
Sep 1, 1988·The American Journal of Physiology·V M Miller, P M Vanhoutte
Sep 1, 1986·The American Journal of Physiology·V M MillerP M Vanhoutte
Sep 1, 1973·The British Veterinary Journal·J B Glen, W N Scott
Aug 1, 1981·Journal of Biomechanical Engineering·R M NeremJ F Cornhill
May 1, 1980·Stroke; a Journal of Cerebral Circulation·C Nordborg, B B Johansson
Jun 1, 1995·Journal of Applied Physiology·M D DelpE M Hasser
Jan 1, 1993·Journal of Cardiovascular Pharmacology·B L Langille
Feb 1, 1995·The American Journal of Physiology·L OlmosP M Vanhoutte
May 1, 1994·Journal of Applied Physiology·R D Roer, R M Dillaman
Dec 1, 1993·Journal of Applied Physiology·M D DelpE M Hasser
Sep 1, 1993·Journal of Applied Physiology·M D DelpM H Laughlin
Jun 1, 1993·Journal of Applied Physiology·Y KawaiA R Hargens
Jan 1, 1993·Journal of Applied Physiology·M A FreyR T Meehan
Jul 1, 1996·Journal of Applied Physiology·J C BuckeyC G Blomqvist
Aug 1, 1996·Medicine and Science in Sports and Exercise·A R Hargens, D E Watenpaugh
Feb 14, 1998·Journal of Applied Physiology·R ZhangB D Levine
Feb 4, 1998·Hypertension·D L MattsonA W Cowley
Oct 1, 1998·European Journal of Applied Physiology and Occupational Physiology·L SomodyG Gauquelin-Koch
Oct 7, 1998·Journal of Applied Physiology·R E PurdyD Sara
Nov 6, 1998·Journal of Applied Physiology·G G GearyS P Duckles
Mar 10, 1999·The American Journal of Physiology·C R WoodmanE M Price
Dec 22, 1999·Journal of Applied Physiology·M K WilkersonM D Delp
Apr 6, 2000·Journal of Applied Physiology·R C Looft-Wilson, C V Gisolfi
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M D DelpJ Muller-Delp
Jul 25, 2000·Journal of Applied Physiology·N D VaziriR E Purdy
May 18, 2001·Journal of Applied Physiology·L N ZhangJ Ma
Sep 1, 1981·Acta Astronautica·O G GazenkoA D Egorov
Nov 22, 2001·Journal of Applied Physiology·L F Zhang
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M Keith WilkersonMichael D Delp

❮ Previous
Next ❯

Citations

Oct 26, 2012·Cell Biochemistry and Biophysics·Hongyan KangXiaoyan Deng
Jul 19, 2011·Archives of Physical Medicine and Rehabilitation·Jill M WechtWilliam A Bauman
May 7, 2008·Vascular Pharmacology·Scott M SummersRalph E Purdy
Aug 12, 2015·The Journal of Physiology·Zhongchao WangJunxiang Bao
Jun 30, 2011·Clinical and Experimental Pharmacology & Physiology·Xin-Ling RenJin Ma
Jul 6, 2014·Pflügers Archiv : European journal of physiology·Hongyan KangXiaoyan Deng
Mar 13, 2015·Journal of Physiology and Biochemistry·Zhong-Chao WangJin Ma
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·M Keith WilkersonMichael D Delp
Nov 30, 2005·Immunological Reviews·Majd ZayzafoonJay M McDonald
Mar 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick J MuellerEileen M Hasser
Jun 1, 2007·Journal of Addiction Medicine·Marc J KaufmanDomenic A Ciraulo
Oct 16, 2010·Cell Biology International·Gabriella TedeschiAngela Maria Rizzo
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jana RudnickDieter Blottner
Jun 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min JiangRan Zhang
Jun 9, 2019·Clinical and Experimental Pharmacology & Physiology·Hongyan KangXiaoyan Deng
Nov 4, 2006·Journal of Applied Physiology·Eric C TudayDan E Berkowitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.