Effects of single and repeated administration of sulthiame on amygdaloid kindled seizures in rats

Epilepsy Research
H K SongM Seino

Abstract

In this study, we assessed the anti-convulsive effects of sulthiame (SUL) in amygdaloid (AM) kindled rats. Electrodes were implanted into the left AM of adult male Wistar rats. The animals were kindled at the after-discharge (AD) threshold. Upon completion of kindling, a generalized seizure triggering threshold was determined. The drugs were administered intraperitoneally in rats which reproducibly exhibited generalized convulsions at the near-threshold stimulation. Single administration of SUL (25-200 mg; n = 7-9) reduced the forelimb clonus (FCL) duration, but only the highest dose significantly regressed the secondarily generalized convulsion. During repeated administration of SUL, 50 mg/kg for 8 days, FCL duration was significantly alleviated until the fifth treatment day. With the dose of 200 mg/kg, significant suppression of secondary generalization was noted only until the second test day. On the other hand, significant reductions of FCL and AD duration were preserved afterwards. The anti-convulsive effects of SUL indicated in this study were not comparable to those of other standard anti-epileptic drugs reported from our laboratory.

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Sep 1, 1974·Epilepsia·J R GreenP Kanarek
Aug 1, 1984·Neuropharmacology·T E AlbertsonR M Joy
Oct 1, 1984·Neuropharmacology·T E AlbertsonL G Stark
Jul 1, 1980·Neuropharmacology·T E AlbertsonL G Stark

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Citations

Aug 26, 1998·Epilepsy Research·K AmanoM Seino
Jul 21, 2004·Il Farmaco·P YogeeswariJ P Stables

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