Effects of single dose irradiation on pancreatic beta-cell function

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Y SarriR Gomis


We have irradiated abdominal cavity of 23 rats with 10 Gy irradiation-induced hypoglycemia on the fourth day after intervention. Islets collected at this time showed an impaired insulin secretion without affecting insulin content. This impairment persisted after one month follow-up with reduced number of beta-cells in morphological examination.


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Related Concepts

Carcinoma, Cribriform
Dose-Response Relationship, Radiation
Islets of Langerhans
Malignant Neoplasm of Pancreas
Radiation Syndrome
Radiation Injuries, Experimental
Radiotherapy Dosage

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