PMID: 7536843Nov 1, 1994Paper

Effects of single doses and daily melatonin treatments on serotonin metabolism in rat brain regions

Journal of Pineal Research
J M MiguezM Aldegunde

Abstract

The acute effects of two doses (0.5 and 1 mg/kg) of melatonin on the levels of tryptophan, serotonin, and 5-hydroxyindoleacetic acid in several rat brain regions were studied. Tryptophan content in the brain regions was unchanged by the treatments. Melatonin at a dosage of 0.5 mg/kg increased medial hypothalamic serotonin levels at 60 and 90 min after the injection. However, the dose of 1 mg/kg increased the levels of this amine or its metabolite in the preoptic area-anterior hypothalamus, medial and posterior hypothalamus, amygdala, and midbrain. These results suggest a specific regional sensitivity to melatonin as well as a dose-dependent response. The stimulatory melatonin effect on the serotoninergic system was also observed after a daily treatment with this hormone (0.5 mg/kg, twice daily during 10 days) in both intact or pinealectomized rats. In intact rats, melatonin treatment increased the levels of 5-hydroxyindole-3-acetic acid in the preoptic area-anterior hypothalamus and medial hypothalamus, while in pinealectomized rats melatonin increased the serotonin content in the medial hypothalamic region. The data support the idea that melatonin has a selective action on serotonin metabolism in regions that contain serotonin...Continue Reading

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Citations

Jan 9, 2008·Behavior Genetics·David A NielsenMary Jeanne Kreek
Jan 16, 1998·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·R Sandyk
Feb 18, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anna HaduchWładysława A Daniel
Feb 1, 1996·The International Journal of Neuroscience·R Sandyk
Dec 1, 1995·The International Journal of Neuroscience·R Sandyk
Mar 20, 2003·Drug and Chemical Toxicology·Haseeb Ahmad Khan
Feb 17, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·R I Caamaño-TubíoM Aldegunde
Mar 6, 2010·Annals of the New York Academy of Sciences·Vadim YuferovMary Jeanne Kreek
Feb 21, 2006·Neuroscience Letters·Shimon AmirBarry Robinson
Jul 7, 2011·Journal of Psychopharmacology·Sergio Domínguez-LópezGabriella Gobbi
Aug 5, 1998·The American Journal of Physiology·O RégrignyI Lartaud-Idjouadiene

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