Effects of single doses of 1-hydroxyethylidene-1,1-bisphosphonate on the mineralizing front of rat incisor enamel: a microradiographic and scanning electron microscopic study

Archives of Oral Biology
V WeileO Fejerskov

Abstract

The effects of a single dose of HEBP were examined by injecting rats subcutaneously with various doses (0.5, 1, 2.5, 5 and 10 mg P/kg body wt) and killing them either 2 or 9 days after injection. The maxillary incisors were processed for microradiography and the mandibular incisors for scanning electron microscopy after enzymatic digestion of the enamel organ remains. All doses resulted in a hypomineralized incremental band corresponding to the position of the mineralizing front at the time of injection. At 5 and 10 mg P/kg body wt, a hypomineralized lesion was found throughout the whole thickness of the enamel in an area which corresponded to the stage of late enamel secretion at the time of injection. The surface layer covering this lesion was elevated or disrupted. By scanning electron microscopy, there were three different types of lesions along the enamel surface: a "demarcation groove" corresponding to the initial enamel formation at the time of injection; an "area containing mineral globules" and a "bright band" corresponding to the stages of late secretory and final enamel formation, respectively, at the time of injection. A single injection of HEBP thus interferes with different stages of enamel formation. The findings...Continue Reading

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Citations

Feb 20, 2016·Environmental Toxicology and Pharmacology·Ana Prates SoaresAlexandre Ribeiro do Espírito Santo
Apr 24, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Rajesh Gutta, Patrick J Louis
Jan 1, 1995·Connective Tissue Research·C BrandstenL Hammarström
May 24, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Ana P SoaresAlexandre R do Espírito Santo
Feb 1, 1996·Acta Odontologica Scandinavica·I Alatli, L Hammarström
Nov 1, 1996·Advances in Dental Research·K SatoT Aoba
Feb 8, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Luciana F MassaVictor E Arana-Chavez
Mar 12, 1998·Endocrine Reviews·H Fleisch
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Silvia M A João, Victor E Arana-Chavez

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