Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats

Endocrinology
S TovarManuel Tena-Sempere

Abstract

The ability of kisspeptins, ligands of the G protein-coupled receptor 54, to potently elicit LH secretion is now undisputed. Yet, most of the pharmacological characterization of their gonadotropin-releasing effects has been conducted after intracerebral administration. In contrast, the effects of peripheral injection of kisspeptin remains less well defined. In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats. LH responsiveness to peripheral administration of kisspeptin appeared extremely sensitive, as doses as low as 0.3 nmol/kg (0.1 microg/rat) evoked robust LH bursts, the magnitude of which was dose-dependent and apparently maximal in response to 3.0 and 30 nmol/kg kisspeptin-10. The ability of kisspeptin-10 to stimulate LH release was fully preserved, and even doubled in terms of relative increases, after short-term fasting despite suppression of prevailing LH levels. Repeated injections of kisspeptin-10 (four boluses, at 75-min intervals) evoked associated LH secretory pulses, the magnitude of which remained constant...Continue Reading

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Citations

Jan 9, 2007·Reviews in Endocrine & Metabolic Disorders·Wendy Kuohung, Ursula B Kaiser
Mar 7, 2007·Reviews in Endocrine & Metabolic Disorders·Victor M NavarroManuel Tena-Sempere
Mar 10, 2011·Endocrine·Yathindar S RaoToni R Pak
Jul 25, 2009·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Tena-Sempere
Jul 3, 2013·Nature Reviews. Endocrinology·Robert P Millar, Claire L Newton
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Han Kyoung ChoeKyungjin Kim
Dec 26, 2008·Human Reproduction Update·A K Roseweir, R P Millar
Aug 18, 2006·Current Opinion in Pediatrics·Manuel Tena-Sempere
Jun 29, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Víctor M Navarro, Ursula B Kaiser
Mar 13, 2012·Reproductive Biology and Endocrinology : RB&E·Faiqah RamzanFaiza Ramzan
Sep 28, 2012·Endocrinology·Jyothis T George, Stephanie B Seminara
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Mar 13, 2014·Human Reproduction Update·Karolina SkorupskaiteRichard A Anderson

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