Effects of sinus surgery on lung transplantation outcomes in cystic fibrosis

American Journal of Rhinology
Man-Kit LeungPeter H Hwang

Abstract

In cystic fibrosis (CF) patients who are candidates for lung transplant, pretransplant sinus surgery has been advocated to avoid bacterial seeding of the transplanted lungs. This study reviews the 17-year experience of pretransplant sinus surgery among CF patients at a major transplant center. Retrospective chart review was performed in all CF patients who underwent heart-lung or lung transplantation at Stanford Medical Center between 1988 and 2005. Postoperative culture data from bronchoalveolar lavage (BAL) and sinus aspirates were evaluated, in addition to survival data. Eighty-seven CF transplant recipients underwent pretransplant sinus surgery; 87% (n=59/68) of patients showed recolonization of the lung grafts with Pseudomonas on BAL cultures. The median postoperative time to recolonization was 19 days. Bacterial floras cultured from sinuses were similar in type and prevalence as the floras cultured from BAL. When compared with published series of comparable cohorts in which pretransplant sinus surgery was not performed, there was no statistically significant difference in the prevalence of Pseudomonas recolonization. Times to recolonization also were similar. Survival rates in our cohort were similar to national survival ...Continue Reading

References

Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·P A FlumeJ R Yankaskas
Sep 2, 1998·The Annals of Thoracic Surgery·T M EganL J Paradowski
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·D NunleyK Peterson
Oct 9, 2001·International Journal of Pediatric Otorhinolaryngology·K W RosbeA D Auerbach
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Jul 18, 2002·The Annals of Thoracic Surgery·Luca A VricellaBruce A Reitz
Feb 11, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan D MoffattRichard I Whyte
Dec 22, 2005·The Annals of Thoracic Surgery·Susan D Moffatt-BruceBruce A Reitz
May 30, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Zohra BendouahMartin Desrosiers
Apr 5, 2007·The Journal of Antimicrobial Chemotherapy·Alexander G ChiuNoam A Cohen
Apr 10, 2007·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·J E SpahrK C Meyer
May 1, 2007·Clinics in Chest Medicine·Steven D Strausbaugh, Pamela B Davis

❮ Previous
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Citations

Sep 27, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kasper Aanæs
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Dana L WillnerDaniel C Chambers
Dec 21, 2013·Archivos de bronconeumología·José Manuel Vaquero BarriosFrancisco Santos Luna
Mar 31, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Domenic VitalDavid Holzmann
Apr 20, 2012·International Journal of Pediatric Otorhinolaryngology·G Paul DigoyDwight T Jones
May 7, 2014·Pulmonary Medicine·T O HircheUNKNOWN ECORN-CF Study Group
Mar 13, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Oana CiofuNiels Høiby
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D van DuinUNKNOWN AST Infectious Diseases Community of Practice
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C van DeldenUNKNOWN AST Infectious Diseases Community of Practice
Apr 10, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·P WilsonC Pao
May 28, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C CerveraUNKNOWN ESCMID Study Group for Infections in Compromised Hosts
Jan 28, 2014·The Lancet. Respiratory Medicine·Leonard J Lobo, Peadar G Noone
May 19, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Helle Krogh JohansenChristian von Buchwald
Aug 13, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Winnie RidderbergNiels Nørskov-Lauritsen
Jul 30, 2016·Pediatric Clinics of North America·Albert Faro, Alexander Weymann
Nov 5, 2016·Acta Oto-laryngologica·Shin KariyaKazunori Nishizaki
Jun 22, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sonya MalekzadehMatthew K Steehler
Nov 25, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew K SteehlerSonya Malekzadeh
Dec 15, 2017·International Forum of Allergy & Rhinology·Kevin J ChoiDavid W Jang
Sep 2, 2017·American Journal of Rhinology & Allergy·Maria E MøllerChristian von Buchwald
Feb 15, 2013·American Journal of Rhinology & Allergy·Kasper AanaesHelle Krogh Johansen
Sep 11, 2018·Expert Review of Respiratory Medicine·Susan S LiDon Hayes
Dec 9, 2008·Current Opinion in Organ Transplantation·Paul A Corris
Sep 18, 2010·Current Opinion in Infectious Diseases·Me-Linh LuongShahid Husain
Dec 7, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Dana L Crosby, Nithin D Adappa
Sep 1, 2017·Current Opinion in Pulmonary Medicine·Lieven Dupont
Dec 10, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Michael T Chang, Zara M Patel
Apr 10, 2019·Medical Sciences : Open Access Journal·Zhong ZhengDavid A Gudis
Jul 1, 2020·Laryngoscope Investigative Otolaryngology·Brian Jake JohnsonErin K O'Brien
Feb 22, 2017·International Forum of Allergy & Rhinology·Noel AyoubPeter H Hwang
Jan 29, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Paolo LuparelloGiandomenico Maggiore
Nov 23, 2016·Frontiers in Microbiology·Marie BeaumeUNKNOWN Swiss Transplant Cohort Study
Feb 4, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kathleen J RamosJennifer L Taylor-Cousar
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Apr 4, 2021·Journal of Clinical Medicine·Anna Engell HolmMichael Perch
Jun 10, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pali ShahRamsey R Hachem
Aug 23, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lorriana E LeardKathleen J Ramos
Jul 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity
Dec 8, 2021·International Forum of Allergy & Rhinology·Joseph R JohnsonZara M Patel

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Methods Mentioned

BETA
lavage
bronchoalveolar
biopsy

Software Mentioned

SPSS

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