Effects of sizes and conformations of fish-scale collagen peptides on facial skin qualities and transdermal penetration efficiency.

Journal of Biomedicine & Biotechnology
Huey-Jine ChaiChang-Jer Wu

Abstract

Fish-scale collagen peptides (FSCPs) were prepared using a given combination of proteases to hydrolyze tilapia (Oreochromis sp.) scales. FSCPs were determined to stimulate fibroblast cells proliferation and procollagen synthesis in a time- and dose-dependent manner. The transdermal penetration capabilities of the fractionationed FSCPs were evaluated using the Franz-type diffusion cell model. The heavier FSCPs, 3500 and 4500 Da, showed higher cumulative penetration capability as opposed to the lighter FSCPs, 2000 and 1300 Da. In addition, the heavier seemed to preserve favorable coiled structures comparing to the lighter that presents mainly as linear under confocal scanning laser microscopy. FSCPs, particularly the heavier, were concluded to efficiently penetrate stratum corneum to epidermis and dermis, activate fibroblasts, and accelerate collagen synthesis. The heavier outweighs the lighter in transdermal penetration likely as a result of preserving the given desired structure feature.

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Citations

May 28, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Vincenza FerraroManuela E Pintado
Dec 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Manika VijMunia Ganguli
Aug 6, 2015·Journal of Food Science and Technology·Fazli SubhanAbdul Ghafoor
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Jan 24, 2015·Journal of Biomaterials Applications·Shih-Bin LinHui-Huang Chen
Jun 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chi-Hao WangSan-Lang Wang
Feb 27, 2020·Antioxidants·Gabriel Aguirre-CruzGabriel Aguirre-Álvarez
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreea IosageanuFlorin Oancea

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Methods Mentioned

BETA
ELISA
gel filtration
fluorescence microscopy
protein assay
confocal spectral microscopy

Software Mentioned

SigmaPlot
SigmaStat

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