Effects of sleep deprivation and aging on long-term and remote memory in mice

Learning & Memory
Christopher G VecseyTed Abel

Abstract

Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.

References

May 1, 1992·Science·J J Kim, M S Fanselow
Sep 1, 1986·Journal of Gerontology·D K WelshW C Dement
Mar 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
Oct 8, 1999·Behavioural Brain Research·H Eichenbaum
Dec 22, 1999·Seminars in Cell & Developmental Biology·M J Gething
Apr 13, 2001·Current Opinion in Neurobiology·T Abel, K M Lattal
Nov 1, 2002·Neuron·Jacek DebiecKarim Nader
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Nov 19, 2003·Biochemical and Biophysical Research Communications·Isabelle M Mansuy
Jun 9, 2004·The European Journal of Neuroscience·David N RuskinGerald J LaHoste
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Feb 18, 2005·Journal of Neurochemistry·Nirinjini NaidooAllan I Pack
Mar 1, 2005·Biochimie·David Carling
Apr 12, 2005·Experimental Gerontology·Orla P HornungIsabella Heuser
Dec 24, 2005·Nature Reviews. Neuroscience·Sara N Burke, Carol A Barnes
May 12, 2006·Chronobiology International·Christian CajochenAnna Wirz-Justice
Jul 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cátia M TeixeiraPaul W Frankland
Aug 3, 2006·Learning & Memory·Paul W FranklandAlcino J Silva
Nov 8, 2006·Neuron·Anastassios V Tzingounis, Roger A Nicoll
May 12, 2007·The Journal of Clinical Investigation·Emira AyroldiCarlo Riccardi
Mar 26, 2008·Psychology and Aging·Susan R Old, Moshe Naveh-Benjamin
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·R Jonathan RobitsekHoward Eichenbaum
Jan 27, 2009·Biological Psychiatry·Charles L PickensYavin Shaham
Jul 21, 2009·Neuropharmacology·Sachiko ChikahisaHiroyoshi Séi
Oct 23, 2009·Nature·Christopher G VecseyTed Abel
Feb 26, 2010·Memory·Mariam Aly, Morris Moscovitch
May 25, 2010·Nature Neuroscience·Courtney A MillerJ David Sweatt
Jul 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Markus DworakRadhika Basheer
Jul 14, 2010·Neurobiology of Aging·Sibah HasanMehdi Tafti
Apr 12, 2011·International Journal of Cancer. Journal International Du Cancer·Marie MetzigMichael Boutros
Oct 25, 2011·Cell·Inbal GoshenKarl Deisseroth
Jun 2, 2012·Sleep·Faith S LuysterUNKNOWN Boards of Directors of the American Academy of Sleep Medicine and the Sleep Research Society
Aug 30, 2012·Physiological Genomics·Christopher G VecseyTed Abel
Sep 19, 2012·Frontiers in Aging Neuroscience·Thomas C FosterJennifer L Bizon

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Citations

Jan 2, 2018·Pathobiology of Aging & Age Related Diseases·Anna SchorrWarren Ladiges
Aug 5, 2020·GeroScience·Arehally M MahalakshmiMeena Kishore Sakharkar
Mar 15, 2018·Frontiers in Neural Circuits·Marie E GaineTed Abel
Jan 28, 2020·Nutrition and Healthy Aging·Arjun Sengupta, Aalim M Weljie
Mar 20, 2018·Neurobiology of Learning and Memory·Christopher G VecseyTed Abel

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