Effects of Sleeve Gastrectomy on Serum 12α-Hydroxylated Bile Acids in a Diabetic Rat Model

Obesity Surgery
Minggang WangGuang-yong Zhang

Abstract

Diabetes mellitus is a prevalent disease that endangers human health. Bariatric surgery can effectively relieve insulin resistance with elevated serum bile acids (BAs). 12α-Hydroxylated BAs were previously reported to be associated with insulin resistance. The aim of this study was to analyze changes in 12α-hydroxylated BA composition and possible associated mechanisms in diabetic rats following sleeve gastrectomy (SG). SG and sham operations were performed in diabetic rats induced by high-fat diet feeding and streptozotocin. Body weight, food intake, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), and serum BAs were analyzed at corresponding time points. Cholesterol 12α-hydroxylase (CYP8B1) and transcription factor V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G (MAFG) expression levels were assessed by RT-PCR and western blotting. Compared with the SHAM group, the SG group displayed significant weight loss from 6 weeks postoperatively, accompanied by decreased food intake from 4 weeks after the operation. At 2 and 12 weeks postoperatively, the areas under the curve of OGTT and ITT were significantly decreased in the SG group. At 12 weeks post-operation, the SG group displayed elevated serum BA...Continue Reading

References

Sep 27, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ines BurkardKatharina M Rentsch
Jan 10, 2006·Methods in Enzymology·Erin M ShonseyStephen Barnes
Dec 11, 2007·Obesity Surgery·Fàtima Sabench PereferrerDaniel del Castillo Déjardin
Jul 1, 2008·Nature Medicine·Sudha B BiddingerC Ronald Kahn
Sep 18, 2009·Trends in Pharmacological Sciences·Stefano FiorucciSabrina Cipriani
Jul 14, 2010·Annals of Surgery·Jacques HimpensGeert Peeters
Nov 15, 2011·Diabetes Research and Clinical Practice·David R WhitingJonathan Shaw
Jul 20, 2012·Biochemical and Biophysical Research Communications·Gerald Ulrich DenkChristian Rust
Mar 5, 2013·The Journal of Clinical Endocrinology and Metabolism·Rohit KohliSamuel Klein
Apr 23, 2013·Cell Metabolism·Thomas Q de Aguiar VallimPeter A Edwards
Apr 23, 2013·The International Journal of Biochemistry & Cell Biology·Brittnee L Zwicker, Luis B Agellon
Oct 24, 2014·Diabetes·Achint KaurMichael R Hayden
Jan 15, 2015·Current Opinion in Gastroenterology·Tiangang Li, John Y L Chiang
Feb 5, 2015·Cell Metabolism·Thomas Q de Aguiar VallimPeter A Edwards
Apr 4, 2015·Obesity Surgery·L AngrisaniN Scopinaro
Mar 10, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R DutiaB Laferrère
May 26, 2016·Diabetes Care·Francesco RubinoUNKNOWN Delegates of the 2nd Diabetes Surgery Summit

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Citations

Nov 19, 2019·International Journal of Endocrinology·Mengsiyu LiShuguang Pang
May 16, 2019·Journal of Zhejiang University. Science. B·Li-Hua JinWen-Dong Huang

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