PMID: 9168369May 1, 1997Paper

Effects of small-peptide and whole-protein enteral feedings on serum proteins and diarrhea in critically ill patients: a randomized trial

JPEN. Journal of Parenteral and Enteral Nutrition
D C HeimburgerC Keeney

Abstract

It has been proposed that enteral feeding formulas containing small peptides are more efficacious and better tolerated than whole-protein formulas in critically ill patients. Intensive care unit patients were stratified with regard to treatment with antibiotics and serum albumin and randomized to treatment with a small-peptide enteral diet or an isoenergetic, isonitrogenous whole-protein diet for 10 days. To assess efficacy, we measured serum prealbumin and fibronectin, and to assess tolerance, we monitored the incidence of diarrhea. A protocol was followed to ascertain all causes of diarrhea (defined as > 200 g stool or > or = 3 liquid stools on 2 consecutive days). Fifty subjects completed the trial. Serum prealbumin and fibronectin increased between 21% and 36% in both groups, but the increase was significant only in the small-peptide group. The change in fibronectin between days 5 and 10 was significantly greater in the small-peptide group (p = .02). Diarrhea occurred in 10 subjects (17.8% of days) receiving small-peptide feeding and 4 subjects (7.5% of days) receiving whole-protein feeding (P = .07 for incidence and 0.03 for prevalence), but the difference was explained by the coincidental use of more diarrhea-causing medi...Continue Reading

References

Jan 1, 1992·Critical Care Medicine·M S Oh, H J Carroll
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·D B HillC J McClain
Aug 1, 1991·Boletín médico del Hospital Infantil de México·D Pizarro-Torres
May 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·C ViallW P Steffee
Jun 1, 1990·Journal of the American Geriatrics Society·A G FellerD Rudman
Apr 1, 1989·Critical Care Medicine·R R Brinson, W M Pitts
Jul 1, 1986·Gastroenterology·P B McIntyreJ E Lennard-Jones
May 1, 1987·Critical Care Medicine·R R Brinson, B E Kolts
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·L HowardE Cho
Jun 1, 1983·The Journal of Experimental Medicine·C G PommierE J Brown
Oct 22, 1982·JAMA : the Journal of the American Medical Association·R L ScottM G MacDonald

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Citations

Nov 26, 2009·Journal of Neurotrauma·Christine CharrueauChristophe Moinard
Jun 11, 2002·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Patti Eisenberg
Dec 6, 2011·Critical Care : the Official Journal of the Critical Care Forum·Michael P Casaer, Dieter Mesotten
Feb 26, 2014·Annales Françaises D'anesthèsie Et De Rèanimation·J-Y LefrantUNKNOWN Société francophone nutrition clinique et métabolique
Apr 23, 2008·Journal of Advanced Nursing·Melissa A L ThorsonKay Savik
Feb 21, 2003·Intensive Care Medicine·Jean-Charles PreiserUNKNOWN ESICM(European Society of Intensive Care Medicine) Working Group on Nutrition and Metabolism
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K G KreymannUNKNOWN ESPEN (European Society for Parenteral and Enteral Nutrition)
Mar 4, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J P MonteiroD F Cunha
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·David S Seres
Nov 26, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Jacqueline S BarrettPeter R Gibson
Aug 16, 2002·Clinical Nursing Research·Neva L CroganRobert A Short
May 14, 2003·Clinical Nursing Research·Kelly J LebakKathleen M Patten-Marsh
Oct 4, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Arlene A Escuro, A Christine Hummell
Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jason M Hollander, Jeffrey I Mechanick
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Dominik D AlexanderDouglas L Nguyen
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·S Cattan, J Cosnes
Jan 18, 2012·Journal of Pediatric Gastroenterology and Nutrition·Maria V M VidigalPaulo C K Nogueira
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jody A Weckwerth
Mar 27, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Anil Minocha
Jun 27, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Sue-Joan Chang, Hsiu-Hua Huang
Dec 4, 2020·Nutrients·Lee-Anne S ChappleMarianne J Chapman
Jan 22, 2021·Critical Care : the Official Journal of the Critical Care Forum·Laurent CarteronGuillaume Besch

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