PMID: 7966841Nov 16, 1994Paper

Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study

JAMA : the Journal of the American Medical Association
N R AnthonisenP O'Hara


To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV1) in smokers aged 35 to 60 years who have mild obstructive pulmonary disease. Randomized clinical trial. Participants randomized with equal probability to one of the following groups: (1) smoking intervention plus bronchodilator, (2) smoking intervention plus placebo, or (3) no intervention. Ten clinical centers in the United States and Canada. A total of 5887 male and female smokers, aged 35 to 60 years, with spirometric signs of early chronic obstructive pulmonary disease. Smoking intervention: intensive 12-session smoking cessation program combining behavior modification and use of nicotine gum, with continuing 5-year maintenance program to minimize relapse. Bronchodilator: ipratropium bromide prescribed three times daily (two puffs per time) from a metered-dose inhaler. Rate of change and cumulative change in FEV1 over a 5-year period. Participants in the two smoking intervention groups showed significantly smaller declines in FEV1 than did those in the control group. Most of this difference occurred during the first year following entry into the stu...Continue Reading

Associated Clinical Trials


Jun 13, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Katsuya OnishiPaul W Jones
May 3, 2012·Proceedings of the American Thoracic Society·Ann G Schwartz
Feb 14, 2003·Lancet·Stephen I Rennard
May 3, 2014·Annals of Thoracic Medicine·Javed H KhanMohamed S Al-Hajjaj
Nov 20, 2013·American Journal of Respiratory and Critical Care Medicine·Hye Yun ParkD D Sin
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Avrum SpiraJerome S Brody
Feb 21, 2014·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboEvaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study Investigators
Nov 26, 2009·Psychosomatic Medicine·Erik J GiltayDaan Kromhout
Apr 24, 2014·Annals of the American Thoracic Society·M Bradley DrummondStephen I Rennard
May 31, 2014·American Journal of Respiratory and Critical Care Medicine·J Michael WellsJ Edwin Blalock
Apr 11, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John R HughesPeter W Callas
Feb 22, 2012·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Andreas von LeupoldtThomas Ritz
Jun 19, 2013·Computer Methods and Programs in Biomedicine·Chen-Ling HuangWen-Shan Jian
Mar 26, 2003·Seminars in Thoracic and Cardiovascular Surgery·Konrad E BlochWalter Weder
Mar 26, 2003·Seminars in Thoracic and Cardiovascular Surgery·Roger D YusenKathy L Brown
Mar 6, 2009·Journal of the American Medical Informatics Association : JAMIA·Blanca E HimesMarco F Ramoni
Sep 1, 1995·Thorax·M J Jarvis
Oct 28, 1995·BMJ : British Medical Journal·J Foulds, C Godfrey
Aug 24, 1999·BMJ : British Medical Journal·H A Kerstjens
Mar 4, 2003·Thorax·W MacNee, P M Calverley
Sep 23, 2003·BMJ : British Medical Journal·Hannah Jackson, Richard Hubbard
Dec 4, 2003·Thorax·P A DawkinsR A Stockley
Jun 1, 2005·Tobacco Control·F Byrne, S Chapman

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