PMID: 9432318Mar 1, 1997Paper

Effects of smoking on cure of Helicobacter pylori infection and duodenal ulcer recurrence in patients treated with clarithromycin and omeprazole

Helicobacter
K D BardhanC O'morain

Abstract

Smoking may affect adversely the cure rate for Helicobacter pylori infection in patients treated with amoxicillin and omeprazole. Therapy with clarithromycin and omeprazole was tested for its effectiveness in the treatment of H. pylori infection in smokers and nonsmokers. Patients with verified duodenal ulcer and H. pylori infection received clarithromycin 500 mg tid, in combination with omeprazole 40 mg/ day, for 2 weeks, followed by omeprazole (20 or 40 mg daily) for 2 additional weeks according to a randomized, double-blind, multicenter design. Patients were analyzed by their smoking status for the cure of H. pylori infection, ulcer healing, and prevention of duodenal ulcer recurrence. After treatment with clarithromycin and omeprazole, H. pylori infection was cured in 71% of the smokers and in 77% of the nonsmokers (evaluated 4-6 weeks after treatment). Overall ulcer healing was 95%, and overall ulcer recurrence was 19%. For H. pylori-negative patients, ulcer recurrence was 12% in both smokers and nonsmokers. None of these values was significantly different when smokers were compared to nonsmokers. Therapy with clarithromycin and omeprazole is effective for cure of H. pylori infection in smokers and nonsmokers. Smoking has ...Continue Reading

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Citations

Jan 17, 2002·Archives of Pharmacal Research·A Crespo, B Suh
Aug 3, 2001·Primary Care·J D Pianka, J Affronti
Feb 24, 2001·Gastroenterology Clinics of North America·H Cohen
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Nov 26, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Young CheungUNKNOWN Korean Association of Gastroenterology
Nov 26, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Su Young KimJun Won Chung
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Jan 19, 2000·The American Journal of Gastroenterology·D Y Graham, M S Osato
Apr 14, 1999·The American Journal of Gastroenterology·A SonnenbergJ Zhang
Apr 13, 2019·Journal of Cellular Biochemistry·Abolfazl Zendehdel, Maryam Roham
May 10, 2003·Scandinavian Journal of Gastroenterology·S Olafsson, A Berstad
Oct 29, 2021·Helicobacter·Jing YuXiaoyong Wang

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