PMID: 3750370Jan 1, 1986Paper

Effects of smoking on nortriptyline plasma concentrations in depressed patients

Therapeutic Drug Monitoring
P J PerryM T Tsuang

Abstract

The pharmacokinetic parameters of half-life, volume of distribution, and steady-state nortriptyline plasma concentration normalized to a 100-mg/day maintenance dose were calculated in nine smokers and 15 nonsmokers. The mean normalized total nortriptyline concentration for the smokers of 118 +/- 33 ng/ml was significantly lower than the nonsmokers' mean value of 158 +/- 35 ng/ml. The mean normalized free plasma concentrations for the smokers of 11.4 +/- 3.5 ng/ml was not different from the nonsmokers' mean concentrations of 11.5 +/- 2.6 ng/ml. The smokers had a slightly higher percentage free drug values of 10.2 +/- 4.0% (p = 0.08) as contrasted to 7.4 +/- 1.5% free nortriptyline for the nonsmokers. The nortriptyline half-life figures for both the free and total drug concentrations did not differ. Multiple linear regression analysis utilizing age, smoking status, sex, liver function, and the presence or absence of enzyme-inducing or -inhibiting drugs as the potential independent variables and percentage free nortriptyline or total nortriptyline concentration as the dependent variable, found that smoking status explained 21% of the variation in the percentage free nortriptyline in the patients and 26% of the variation in the tot...Continue Reading

Citations

Jul 1, 1995·Journal of Traumatic Stress·J C BeckhamJ A Fairbank
Apr 1, 1996·European Journal of Drug Metabolism and Pharmacokinetics·M Jerling
Sep 15, 1990·Biological Psychiatry·D D MillerW H Coryell
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Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Marietta Anthony, Mary J Berg
Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Marietta Anthony, Mary J Berg
Aug 10, 2007·Clinical Pharmacology and Therapeutics·M E MooneyK Delucchi
Jul 26, 2019·Journal of Clinical Psychopharmacology·Maike Scherf-ClavelStefan Unterecker
Dec 13, 2000·International Journal of Geriatric Psychiatry·R C YoungG S Alexopoulos
Sep 10, 2021·Acta Neuropsychiatrica·Nicklas Hasselblad LundstrømMaija Bruun Haastrup

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