Effects of smoking severity and moderate and severe periodontitis on serum C-reactive protein levels: an age- and gender-matched retrospective cohort study

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Arash AziziVahid Rakhshan

Abstract

C-reactive protein (CRP) which might affect cardiovascular events can be affected by chronic diseases and smoking. Since the effects of smoking dosage as well as the mutual effect of smoking and periodontitis on CRP levels have not been evaluated, we aimed to assess these. This retrospective age- and gender-matched study was performed on 120 dental patients. Clinical attachment loss, pocket probing depth (PPD), bleeding on probing (BoP), O'Leary plaque index and serum CRP were recorded. Patients were divided into one control and five cohort groups (n = 20 each) according to smoking severity [pack years (PY) below or above 30] and periodontal condition (healthy periodontium and moderate/severe periodontitis). The effects of clinical measurements, age, gender, smoking and periodontitis on CRP were assessed using one- and two-way analyses of variance, Tukey and Bonferroni post hoc tests, and multiple linear regression (α = 0.05). CRP concentrations were 0.07255 ± 0.009539, 0.09645 ± 0.010625, 0.122235 ± 0.018442, 0.3758 ± 0.187369, 0.81595 ± 0.0410299 and 1.8717 ± 0.652728 mg/l, respectively, in the control (PY ≤ 30 with healthy periodontium), cohort 1 (PY > 30 with healthy periodontium), cohort 2 (PY ≤ 30 with moderate periodonti...Continue Reading

References

Nov 29, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·I Das
Jan 1, 1972·Journal of Periodontology·T J O'LearyJ E Naylor
Oct 1, 1996·Journal of Periodontology·J BeckS Offenbacher
Feb 1, 1997·Clinical and Experimental Immunology·J L EbersoleD E Willmann
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Jan 14, 1999·The New England Journal of Medicine·R Ross
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Dec 10, 1999·Journal of Periodontology·M I FredrikssonB E Asman
Feb 26, 2000·Journal of Dental Research·G D SladeJ S Pankow
Jun 15, 2000·The European Respiratory Journal·S F van Eeden, J C Hogg
Oct 2, 2001·Journal of Periodontology·B NoackE De Nardin
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Mar 15, 2002·The Lancet Infectious Diseases·Maija Leinonen, Pekka Saikku
Aug 23, 2003·Journal of Periodontology·Ronald G CraigAnne D Haffajee
Dec 4, 2003·European Heart Journal·Kåre BuhlinBjörn Klinge
Jan 27, 2004·Journal of Dental Research·K J JoshipuraE B Rimm
Feb 21, 2004·Journal of Periodontology·Toshiyuki SaitoToshihiko Koga
Apr 17, 2004·Journal of Clinical Periodontology·Francesco D'AiutoMaurizio S Tonetti
Jun 3, 2004·Circulation·Sidney C SmithUNKNOWN American Heart Association
Jun 23, 2004·Journal of Periodontal Research·Francesco D'AiutoMaurizio S Tonetti
Sep 1, 2004·The Journal of Biological Chemistry·Steven BlackDavid Samols
Feb 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Navapun CharuruksMathuros Chaiworaporn
Mar 16, 2005·Journal of Clinical Periodontology·G Rutger PerssonStefan Renvert
Aug 2, 2005·Journal of the American College of Cardiology·Amit KheraJames A de Lemos
Sep 3, 2005·Journal of the American Geriatrics Society·Walter A BretzAnne B Newman
Oct 11, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lorraine MarnellTerry W Du Clos
Nov 5, 2005·Journal of Clinical Periodontology·Bruce A DyePanos N Papapanou
Nov 10, 2005·Journal of Periodontology·James D Beck, Steven Offenbacher
May 5, 2006·Journal of Periodontology·Waranuch PitiphatMatthew W Gillman
Jun 1, 2006·Journal of Periodontology·Trang N SalzbergHarvey A Schenkein
Aug 12, 2006·Current Atherosclerosis Reports·Gordon D O Lowe, Mark B Pepys
Sep 12, 2006·European Journal of Internal Medicine·Steven VanderschuerenWilly Peetermans
May 15, 2007·Chest·Dilyara G YanbaevaEmiel F M Wouters
Dec 18, 2007·Journal of Clinical Periodontology·Waranuch PitiphatNawarat Wara-Aswapati
Mar 8, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer O'LoughlinGilles Paradis
Sep 8, 2009·International Journal of Clinical Practice·S Tonstad, J L Cowan
Apr 22, 2010·Journal of Indian Society of Periodontology·Dhruva Kumar GaniPamela Emmadi
Jun 16, 2010·Journal of Clinical Periodontology·Filippo GrazianiFrancesco D'Aiuto

❮ Previous
Next ❯

Citations

Dec 31, 2016·Journal of Clinical Periodontology·Vinay PitchikaJan Kühnisch
Aug 23, 2018·Journal of Clinical Periodontology·Mario RomandiniMassimo Cordaro
Aug 28, 2020·Periodontology 2000·Fábio Sá Carneiro SczepanikHoward C Tenenbaum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.