Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys

Menopause : the Journal of the North American Menopause Society
Carol A ShivelyJ Mark Cline

Abstract

To evaluate the effects of social subordination stress and chronic moderate alcohol consumption on indices of breast and endometrial cancer risk. Forty-six adult, ovariectomized, cynomolgus monkeys (Macaca fascicularis) were trained to voluntarily drink a placebo or a two-drink/day equivalent of ethanol (0.5 g/kg), 5 days a week for 26 months, the latter resulting in average blood alcohol levels of 42 mg/100 mL. Indices of cell proliferation and sex steroid receptor abundance were measured. Compared with dominants, socially subordinate females had increased cell proliferation and proportions of glandular (P < 0.02) and epithelial tissue (P = 0.009) and less stroma (P < 0.02) in endometrium, and increased tissue thickness in breast (P < 0.05). There was no evidence of increased risk of breast or endometrial cancer with chronic moderate alcohol consumption, as indicated by markers of cell proliferation and sex steroid receptor abundance. Chronic moderate alcohol consumption did not effect circulating sex steroid concentrations (all P > 0.10). The adipocyte hormones leptin and adiponectin were correlated with indices of cell proliferation and sex steroid receptor abundance. These observations suggest that social status was more im...Continue Reading

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Citations

Aug 3, 2005·Neuroscience and Biobehavioral Reviews·P E Honess, C M Marin
Aug 2, 2015·Gynecologic Oncology·Sara H OlsonKaren H Lu
Jan 1, 2015·Neurobiology of Stress·Carol A Shively, Stephen M Day
Jan 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Shelley S TworogerSusan E Hankinson
Dec 22, 2020·Neurobiology of Stress·Carol A ShivelyThomas C Register

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