PMID: 6970529Feb 1, 1981Paper

Effects of sodium and chloride on potassium transport by the bullfrog kidney

The American Journal of Physiology
L P SullivanL A Rome

Abstract

We have studied the effect on K transport of reductions in the Na and Cl concentrations of solutions perfusing the isolated bullfrog kidney. We used recently developed techniques for estimating the unidirectional reabsorptive and secretory K fluxes. Reduction of Na and Cl concentrations in the arterial perfusate from 112 and 100 mM to 22 and 10 mM, respectively, inhibited K secretion 82% and K reabsorption 97%. Reduction of only the Na concentration inhibited K secretion 42% but did not affect K reabsorption. Arterial and portal perfusion with 37 mM Na, 23 mM Cl reduced urine Na concentration to 6 mM and Na reabsorption by 59%. However, K secretion rose 88% and reabsorption fell 76%. Arterial and portal perfusates with 37 mM Na, 100 mM Cl reduced urine Na concentration to 2 mM and Na reabsorption by 46%. Still, K secretion was elevated 57% by an increase in urine flow rate. K reabsorption was not reduced. Arterial and portal perfusates with 112 mM Na, 23 mM Cl, and containing SO4 also stimulated K secretion 26% and inhibited K reabsorption 91%. Thus, reduction of perfusate Na concentration to 22 mM inhibited secretion but 37 mM was sufficient to permit stimulation of secretion by low Cl concentrations and by increased tubular f...Continue Reading

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