Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study

The British Journal of Nutrition
Lieke GijsbersJohanna M Geleijnse

Abstract

High Na and low K intakes have adverse effects on blood pressure, which increases the risk for CVD. The role of endothelial dysfunction and inflammation in this pathophysiological process is not yet clear. In a randomised placebo-controlled cross-over study in untreated (pre)hypertensives, we examined the effects of Na and K supplementation on endothelial function and inflammation. During the study period, subjects were provided with a diet that contained 2·4 g/d of Na and 2·3 g/d of K for a 10 460 kJ (2500 kcal) intake. After 1-week run-in, subjects received capsules with supplemental Na (3·0 g/d), supplemental K (2·8 g/d) or placebo, for 4 weeks each, in random order. After each intervention, circulating biomarkers of endothelial function and inflammation were measured. Brachial artery flow-mediated dilation (FMD) and skin microvascular vasomotion were assessed in sub-groups of twenty-two to twenty-four subjects. Of thirty-seven randomised subjects, thirty-six completed the study. Following Na supplementation, serum endothelin-1 was increased by 0·24 pg/ml (95 % CI 0·03, 0·45), but no change was seen in other endothelial or inflammatory biomarkers. FMD and microvascular vasomotion were unaffected by Na supplementation. K supp...Continue Reading

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Citations

Jul 28, 2016·The Journal of Clinical Hypertension·Michelle M Y WongNorm R C Campbell
Nov 4, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Geraldine F CloughAndrew J Chipperfield
Mar 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Weizhong HanMin Li
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Jun 5, 2020·The Journal of Clinical Hypertension·Giovanna ValentinoMónica Acevedo
Jan 29, 2019·The Journal of Clinical Hypertension·Allison W PengStephen P Juraschek
Apr 3, 2020·International Journal of Environmental Research and Public Health·Haiquan XuJunmao Sun
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Apr 17, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Brielle L DotsonSteven K Malin

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