Effects of sodium hyaluronate on wavefront aberrations in dry eye patients

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Kaevalin LekhanontTarinee Sangiampornpanit

Abstract

To investigate the effects of a single instillation of hypotonic 0.18% sodium hyaluronate artificial tears on wavefront aberrations in dry eye patients. Fifty patients with dry eye were recruited into this single-center, prospective, double-masked, randomized controlled trial. Patients were randomly assigned to receive one drop of preservative-free, hypotonic 0.18% sodium hyaluronate (treatment) in one eye and one drop of sterile 0.9% sodium chloride solution (control) in the other eye. Ocular aberrations evaluated by a Hartmann-Shack aberrometer and severity of dry eye symptoms graded by a questionnaire (at baseline, 1, 10, 30, 60, and 120 minutes after instillation) were the main outcome measures. After a single instillation of one drop of the allocated eye drops, there were no statistically significant differences between the treatment and control groups in total higher-order aberrations, coma, and spherical aberrations during the study period (p = 0.40, 0.57, and 0.16, respectively). Although a statistically significant (p = 0.04) decrease from baseline in spherical aberrations was noted in the treatment group at 1 minute following instillation, it gradually increased back to baseline values at later time points. A statisti...Continue Reading

References

Jun 1, 1986·The British Journal of Ophthalmology·L S MengherC C Davey
Jul 1, 1994·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·J LiangJ F Bille
Jun 1, 1993·Acta Ophthalmologica·I TodaK Tsubota
Dec 28, 1999·Optometry and Vision Science : Official Publication of the American Academy of Optometry·L N Thibos, X Hong
May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Jan 29, 2002·American Journal of Ophthalmology·Eiki GotoKazuo Tsubota
Jul 4, 2002·American Journal of Ophthalmology·Shizuka KohToshifumi Mihashi
Dec 25, 2002·Journal of Cataract and Refractive Surgery·Willem J HamentRudy M M A Nuijts
Mar 31, 2004·Ophthalmology·Robert Montés-MicóW Neil Charman
Aug 18, 2004·Journal of Cataract and Refractive Surgery·Robert Montés-MicóJorge L Alió
Apr 27, 2005·Investigative Ophthalmology & Visual Science·Robert Montés-MicóW Neil Charman
Jun 29, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael E JohnsonMike Boulton
Jan 1, 1997·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·C AlbarránJ M Artigas
Dec 19, 2006·Cornea·Kaevalin LekhanontAnun Vongthongsri
Aug 28, 2007·Journal of Cataract and Refractive Surgery·Robert Montés-Micó
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Shizuka KohYasuo Tano
Aug 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Michael Edward JohnsonMike Boulton
Jan 29, 2010·Investigative Ophthalmology & Visual Science·Haixia LiuArthur Bradley
May 25, 2010·Journal of Cataract and Refractive Surgery·Robert Montés-MicóSusana Ortí-Navarro
Oct 23, 2010·The Ocular Surface·Robert Montés-MicóDavid Madrid-Costa
Jan 5, 2011·Journal of Vision·Esther BerrioPablo Artal
Feb 23, 2011·The Ocular Surface·William H RidderJim Li
Apr 10, 2012·Journal français d'ophtalmologie·V BaeyensUNKNOWN Vismed/Hylovis Study Group

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Citations

Feb 26, 2016·The Cochrane Database of Systematic Reviews·Andrew D PuckerJason J Nichols
Jun 17, 2018·The British Journal of Ophthalmology·Shizuka KohVishal Jhanji
Sep 13, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Adrian S Bruce, Louis J Catania
Aug 23, 2020·Diagnostics·Doreen SchmidlLeopold Schmetterer
May 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Carlos Carpena-TorresGonzalo Carracedo

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