Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium

Japanese Journal of Cancer Research : Gann
M HiroseN Ito

Abstract

The effects of sodium nitrite (NaNO2) and catechol or 3-methoxycatechol in combination were examined in male F344 rats. Animals were treated with 0.3% NaNO2 in the drinking water and 0.8% catechol or 2% 3-methoxycatechol in powdered diet for 24 weeks. While catechol or 3-methoxycatechol alone induced low incidences of mild or moderate hyperplasia, simultaneous administration of NaNO2 markedly enhanced the degree of hyperplasia and papilloma formation. In contrast, induction of submucosal hyperplasia and adenomas in the glandular epithelium was reduced. Thus, the results indicate that NaNO2 can modulate the metabolism of antioxidants, so that, possibly via production of new active moieties, targeting of forestomach epithelium is enhanced.

References

Mar 1, 1990·Japanese Journal of Cancer Research : Gann·M HiroseN Ito
Jan 1, 1989·Advances in Cancer Research·N Ito, M Hirose
Mar 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H OhshimaH Bartsch
Aug 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H OhshimaH Bartsch
Mar 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Kikugawa, T Kato
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M Williams
Mar 1, 1984·Carcinogenesis·W KuenzigA H Conney

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Citations

Feb 14, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Zulfiquer HossainScott E Kern
Jun 14, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maria A Andersson, Björn E Hellman
Nov 1, 1993·Japanese Journal of Cancer Research : Gann·M KagawaM Hirose

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