Effects of sodium saccharin and linoleic acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line

Cancer Letters
B OgretmenB C Stark

Abstract

The effects of two food-related chemicals (sodium saccharin and linoleic acid) on the levels of Her2/neu and p53 mRNA in a non-cancerous human breast epithelial cell line (HBL-100) were tested in comparison with the effects of the known tumor promoter phorbol 12-myristate 13-acetate (TPA). Treatments were made both with and without prior treatment with two well-known tumor initiators, N-nitroso-N-methylurea (NMU) or 7,12-dimethylbenz[a]anthracene (DMBA). The effects in general were small, the greatest being increases of 46-67% in Her2/neu mRNA levels in response to treatments with TPA or sodium saccharin following NMU treatments. These results demonstrate that sodium saccharin following NMU treatments might be involved in transcriptional regulation of Her2/neu in HBL-100 cells and suggest that its effects may not be limited to urinary bladder.

References

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·C E Elson
Jun 1, 1992·Regulatory Toxicology and Pharmacology : RTP·C I Chappel
May 8, 1992·Science·S E KernB Vogelstein
Oct 1, 1990·The Journal of Trauma·W UhlH G Beger
Jul 18, 1991·Nature·J Ashby, R S Morrod
Jul 5, 1991·Science·M HollsteinC C Harris
Oct 16, 1991·Journal of the National Cancer Institute·D P RoseC L Meschter
Aug 1, 1991·Regulatory Toxicology and Pharmacology : RTP·L A Woods, J Doull
Nov 22, 1991·Science·B E HendersonM C Pike
Apr 16, 1991·Biochimica Et Biophysica Acta·M J Van de Vijver, R Nusse
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L M MulliganW K Cavenee
Feb 1, 1990·Leukemia·A Butturini, R P Gale
Oct 27, 1989·Science·T TakahashiJ D Minna
Oct 16, 1989·Biochemical and Biophysical Research Communications·D P Rose, J M Connolly
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R M HudziakA Ullrich
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R M HudziakH M Shepard
Apr 17, 1987·Science·B N AmesL S Gold
Jul 1, 1987·Preventive Medicine·B S Reddy
Oct 6, 1985·Nature·J R JenkinsG A Currie
Feb 1, 1994·Current Opinion in Genetics & Development

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